Abbasian Hadi, Hajimolaali Mohammad, Yektadoost Alireza, Zartab Saman
Department of Pharmacoeconomics and Pharmaceutical Administration, Tehran University of Medical Science, Tehran, Iran.
Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
J Res Pharm Pract. 2019 Oct 16;8(3):162-167. doi: 10.4103/jrpp.JRPP_19_42. eCollection 2019 Jul-Sep.
Antibiotic resistance is the main threat to health all over the world. The consumption of antibiotics is one of the factors causing the emergence of multidrug resistance. The purpose of this study was to recognize the patterns, trends, and changes of consumption in Iran and to compare them with those of Organization for Economic Co-operation and Development (OECD) countries.
The data were collected from a national pharmaceutical wholesale data bank. Defined daily dose (DDD) or DDDs per 1000 inhabitants per day (DID) was calculated as a standard indicator for the consumption over 17 years.
Were benchmarked with the consumption of OECD countries. Drug utilization 90% (DU90%) method was used to assess the drug consumption pattern.
The antibiotic consumption jumped up from 33.6 DID to 60 DID from 2000 to 2016. Compared to the average consumption of OECD countries, Iran has consumed antibiotics almost triple times. There were 9-11 chemical substances in the DU90% list during these years. Changes in DU90% list occurred within antibiotics classes during the study period. Although the total consumption growth was equal to 79% during these years, consumption of some pharmacological subgroups such as sulfonamide and aminoglycosides has decreased.
Albeit the existence of surveillance system for health-related infectious diseases, the consumption of antibiotics has increased drastically, which illustrates the necessity of comprehensive and effective national antibiotic stewardship.
抗生素耐药性是全球健康面临的主要威胁。抗生素的使用是导致多重耐药性出现的因素之一。本研究的目的是识别伊朗抗生素使用的模式、趋势和变化，并将其与经济合作与发展组织（经合组织）国家进行比较。
数据收集自国家药品批发数据库。以限定日剂量（DDD）或每千居民每日DDD数（DID）作为17年期间抗生素使用的标准指标进行计算。
以经合组织国家的抗生素使用情况为基准。采用药物利用90%（DU90%）方法评估药物使用模式。
2000年至2016年，伊朗抗生素消费量从33.6 DID跃升至60 DID。与经合组织国家的平均消费量相比，伊朗抗生素消费量几乎高出两倍。这些年DU90%清单中有9 - 11种化学物质。研究期间，DU90%清单中的变化发生在抗生素类别内部。尽管这些年抗生素总消费量增长了79%，但一些药理亚组如磺胺类和氨基糖苷类的消费量有所下降。
尽管存在与健康相关传染病的监测系统，但抗生素消费量仍急剧增加，这表明有必要实施全面有效的国家抗生素管理措施。
