Lane M A, Baer D J, Rumpler W V, Weindruch R, Ingram D K, Tilmont E M, Cutler R G, Roth G S
Molecular Physiology and Genetics Section, Nathan W. Shock Laboratories, National Institute on Aging, National Institutes of Health, Hopkins Bayview Medical Center, Baltimore, MD 21224, USA.
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4159-64. doi: 10.1073/pnas.93.9.4159.
Many studies of caloric restriction (CR) in rodents and lower animals indicate that this nutritional manipulation retards aging processes, as evidenced by increased longevity, reduced pathology, and maintenance of physiological function in a more youthful state. The anti-aging effects of CR are believed to relate, at least in part, to changes in energy metabolism. We are attempting to determine whether similar effects occur in response to CR in nonhuman primates. Core (rectal) body temperature decreased progressively with age from 2 to 30 years in rhesus monkeys fed ad lib (controls) and is reduced by approximately 0.5 degrees C in age-matched monkeys subjected to 6 years of a 30% reduction in caloric intake. A short-term (1 month) 30% restriction of 2.5-year-old monkeys lowered subcutaneous body temperature by 1.0 degrees C. Indirect calorimetry showed that 24-hr energy expenditure was reduced by approximately 24% during short-term CR. The temporal association between reduced body temperature and energy expenditure suggests that reductions in body temperature relate to the induction of an energy conservation mechanism during CR. These reductions in body temperature and energy expenditure are consistent with findings in rodent studies in which aging rate was retarded by CR, now strengthening the possibility that CR may exert beneficial effects in primates analogous to those observed in rodents.
许多对啮齿动物和低等动物进行的热量限制（CR）研究表明，这种营养调控可延缓衰老过程，寿命延长、病理学变化减少以及生理功能维持在更年轻状态等现象都证明了这一点。CR的抗衰老作用被认为至少部分与能量代谢的变化有关。我们正在尝试确定在非人灵长类动物中，对CR是否会产生类似的效应。在自由进食（对照组）的恒河猴中，核心（直肠）体温在2至30岁之间随年龄增长而逐渐下降，而在热量摄入减少30%并持续6年的年龄匹配的猴子中，体温降低了约0.5摄氏度。对2.5岁猴子进行为期1个月的30%热量限制，可使皮下体温降低1.0摄氏度。间接测热法显示，在短期CR期间，24小时能量消耗减少了约24%。体温降低与能量消耗之间的时间关联表明，体温降低与CR期间节能机制的诱导有关。体温和能量消耗的这些降低与啮齿动物研究中的发现一致，在啮齿动物研究中CR延缓了衰老速度，这进一步增强了CR可能在灵长类动物中产生与在啮齿动物中观察到的类似有益作用的可能性。
