科威特人群中 30 个插入/缺失多态性的群体遗传学研究。
Population genetics of 30 insertion/deletion polymorphisms in the Kuwaiti population.
机构信息
Centre for Forensic Science, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, Scotland, UK.
Kuwait Identification DNA Laboratory (KIDL), General Department of Criminal Evidence, Ministry of Interior, Kuwait City, Kuwait.
出版信息
Int J Legal Med. 2020 May;134(3):985-986. doi: 10.1007/s00414-019-02180-4. Epub 2019 Nov 14.
This study evaluates the forensic utility of the 30 insertion and deletion (indel) markers contained in the Qiagen Investigator® DIPplex kit in the Kuwaiti population (n = 150). All but one of the 30 markers were shown to conform to the expectations of the Hardy-Weinberg Equilibrium. Linkage disequilibrium tests showed no statistically significant deviation from independence. The high combined power of discrimination (CPD > 99.999%) and low combined match probability (CMP) of 2.736 × 10 provide a satisfactory level of discrimination, allowing the DIPplex loci to be used as forensic markers for individual identification in Kuwait. The paternity indices indicate the usefulness of the DIPplex kit as a supplementary typing system for challenging paternity cases in Kuwait.
本研究评估了 Qiagen Investigator® DIPplex 试剂盒中包含的 30 个插入/缺失（indel）标记在科威特人群（n=150）中的法医学实用性。30 个标记中有除一个外均符合 Hardy-Weinberg 平衡预期。连锁不平衡检验显示不存在与独立性有统计学意义的偏离。高的联合判别能力（CPD>99.999%）和低的联合匹配概率（CMP）为 2.736×10-4，提供了令人满意的判别水平，允许 DIPplex 基因座用作科威特个体识别的法医标记。亲权指数表明 DIPplex 试剂盒作为科威特有挑战性的亲子案件的补充分型系统是有用的。
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