Santosham M, Kallman C H, Neff J M, Moxon E R
J Infect Dis. 1979 Dec;140(6):1009-12. doi: 10.1093/infdis/140.6.1009.
An epidemiologic survey of meningitis caused by Haemophilus influenzae type b in children aged zero to four years during an 11-year period (January 1965-December 1975) was conducted in the Baltimore, Maryland, metropolitan area to examine recent trends in the incidence of this disease. Cases of H. influenzae meningitis were identified at all 19 hospitals in the city and county of Baltimore and all 41 hospitals in the surrounding area. The population at risk (age, zero to four years) was estimated using yearly birth rates provided by the state of Maryland and U.S. Census information for 1960 and 1970. Yearly age-adjusted incidence was calculated; in contrast to previous studies, there was no significant increase in the annual incidence (range, 12-27; mean, 19.3/100,000 population at risk). Previous reports of recent increases in the incidence of meningitis caused by H. influenzae type b may be due to differences in study techniques.
在11年期间（1965年1月至1975年12月），对马里兰州巴尔的摩市大都市地区0至4岁儿童中由b型流感嗜血杆菌引起的脑膜炎进行了一项流行病学调查，以研究该疾病发病率的近期趋势。在巴尔的摩市和巴尔的摩县的所有19家医院以及周边地区的所有41家医院中确定了b型流感嗜血杆菌脑膜炎病例。利用马里兰州提供的年出生率以及1960年和1970年的美国人口普查信息估算了处于危险中的人群（年龄0至4岁）。计算了年龄调整后的年发病率；与先前的研究相比，年发病率没有显著增加（范围为12 - 27；平均为每10万处于危险中的人群19.3例）。先前关于b型流感嗜血杆菌引起的脑膜炎发病率近期上升的报告可能是由于研究技术的差异。
