Ben Omrane Sioud Olfa, El Ati Zohra, Bouzidi Hassan, Kerkeni Mohsen, Hammami Mohamed
Tunis Med. 2019 Apr;97(4):551-555.
The major cause of death for hemodialysis (HD) patients was cardiovascular morbidity; it was closely related to oxidative stress (OS).
Firstly, to evaluate lipid peroxidation biomarkers on HD patients through measuring malondialdehyde (MDA) and conjugated dienes (CD), and secondly, to follow these parameters after three years undergoing HD.
One hundred patients with end stage renal diseases receiving regular hemodialysis and 100 healthy volunteers were included in this study. Routine chemical data, lipid profile and levels of MDA and CD were measured.
The plasmatic and erythrocyte MDA levels were significantly increased in the HD patients compared to healthy subjects (p <0.001). However, an increased level on erythrocyte CD was only observed between the two study groups (p<0.001). After 3 years, a significant increased level of lipid peroxidation biomarkers was observed.
The disturbance in lipid peroxidation state in HD patients was observed. At three years follow-up, oxidative stress is more pronounced with a significant increase in MDA and CD.
血液透析（HD）患者的主要死因是心血管疾病，这与氧化应激（OS）密切相关。
第一，通过测量丙二醛（MDA）和共轭二烯（CD）评估血液透析患者的脂质过氧化生物标志物；第二，在血液透析三年后跟踪这些参数。
本研究纳入了100例接受定期血液透析的终末期肾病患者和100名健康志愿者。测量常规化学数据、血脂谱以及MDA和CD水平。
与健康受试者相比，血液透析患者的血浆和红细胞MDA水平显著升高（p<0.001）。然而，仅在两个研究组之间观察到红细胞CD水平升高（p<0.001）。三年后，观察到脂质过氧化生物标志物水平显著升高。
观察到血液透析患者脂质过氧化状态紊乱。在三年的随访中，氧化应激更为明显，MDA和CD显著增加。
