First Department of Anesthesiology, People's Hospital of Meizhou City, Meizhou, Guangdong Province, China.
Department of Laboratory Medicine, Jiaying University of Meizhou City, Meizhou, Guangdong Province, China.
BMC Anesthesiol. 2019 Nov 15;19(1):211. doi: 10.1186/s12871-019-0883-7.
We aimed to evaluate a modified endotracheal tube containing upper and lower balloons for anesthetic administration among patients undergoing laparoscopic cholecystectomy.
Ninety patients scheduled to undergo laparoscopic cholecystectomy were randomly allocated to 3 equal groups: group A (conventional tracheal intubation without endotracheal anesthesia); B (conventional tracheal intubation with endotracheal anesthesia); and C (tracheal intubation using a modified catheter under study). Blood pressure, heart rate, angiotensin II level, blood glucose level, airway pressure before anesthesia (T1) were measured immediately after intubation (T2), 5 min after intubation (T3), and immediately after extubation (T4). The post-extubation pain experienced was evaluated using the Wong-Baker Face Pain scale. Adverse reactions within 30 min after extubation were recorded.
Systolic blood pressure, diastolic blood pressure, angiotensin II, and blood sugar level in group C at T2, T3 and T4, and heart rate at T2 and T4 were significantly lower than those in group A (P < 0.05); systolic blood pressure and blood sugar at T4, and angiotensin II levels at T2, T3, and T4 were significantly lower than those in group B (P < 0.05). Patients in group C reported the lowest post-extubation pain (P < 0.05 vs. Group A), and the lowest incidence of adverse events such as nausea, vomiting, and sore throat than that in groups A and B (P < 0.05).
The modified endotracheal anesthesia tube under study is effective in reducing cardiovascular and tracheal stress response, and increasing patient comfort, without inducing an increase in airway resistance.
The clinical trial was retrospectively registered at the Chinese Clinical Trial Registry with the Registration Number ChiCTR1900020832 at January 20th 2019.
本研究旨在评估一种改良的气管导管，该导管在上、下气囊中含有麻醉剂，用于接受腹腔镜胆囊切除术的患者。
90 例行腹腔镜胆囊切除术的患者被随机分为 3 组：A 组（常规气管插管无气管内麻醉）；B 组（常规气管插管加气管内麻醉）；C 组（使用研究中的改良导管插管）。在麻醉前（T1）、插管后即刻（T2）、插管后 5 分钟（T3）和拔管后即刻（T4）测量血压、心率、血管紧张素 II 水平、血糖水平、气道压。采用 Wong-Baker 面部疼痛量表评估拔管后疼痛。记录拔管后 30 分钟内的不良反应。
C 组 T2、T3 和 T4 时的收缩压、舒张压、血管紧张素 II 和血糖水平，以及 T2 和 T4 时的心率均明显低于 A 组（P<0.05）；T4 时的收缩压和血糖水平，以及 T2、T3 和 T4 时的血管紧张素 II 水平均明显低于 B 组（P<0.05）。C 组患者拔管后疼痛评分最低（P<0.05 与 A 组比较），恶心、呕吐和咽痛等不良反应发生率也低于 A 组和 B 组（P<0.05）。
研究中改良的气管内麻醉导管可有效减轻心血管和气管应激反应，提高患者舒适度，同时不会引起气道阻力增加。
该临床试验于 2019 年 1 月 20 日在中国临床试验注册中心进行了回顾性注册，注册号为 ChiCTR1900020832。
