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间充质干细胞的免疫调节作用。

Immune modulation by mesenchymal stem cells.

机构信息

Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Health Science Center, Shenzhen University, Shenzhen, China.

Department of Anatomy, Histology & Developmental Biology, Health Science Center, Shenzhen University, Shenzhen, China.

出版信息

Cell Prolif. 2020 Jan;53(1):e12712. doi: 10.1111/cpr.12712. Epub 2019 Nov 15.

DOI:10.1111/cpr.12712
PMID:31730279
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6985662/
Abstract

Mesenchymal stem cells (MSCs) can be derived from various adult tissues with multipotent and self-renewal abilities. The characteristics of presenting no major ethical concerns, having low immunogenicity and possessing immune modulation functions make MSCs promising candidates for stem cell therapies. MSCs could promote inflammation when the immune system is underactivated and restrain inflammation when the immune system is overactivated to avoid self-overattack. These cells express many immune suppressors to switch them from a pro-inflammatory phenotype to an anti-inflammatory phenotype, resulting in immune effector cell suppression and immune suppressor cell activation. We would discuss the mechanisms governing the immune modulation function of these cells in this review, especially the immune-suppressive effects of MSCs.

摘要

间充质干细胞（MSCs）可来源于多种具有多能性和自我更新能力的成体组织。其特点是不存在重大伦理问题、免疫原性低，并具有免疫调节功能，这使其成为干细胞治疗的有前途的候选者。当免疫系统功能低下时，MSCs 可促进炎症，当免疫系统过度激活时，MSCs 可抑制炎症，以避免自身攻击。这些细胞表达许多免疫抑制剂，将其从促炎表型转换为抗炎表型，从而抑制免疫效应细胞并激活免疫抑制细胞。我们将在本综述中讨论这些细胞的免疫调节功能的调控机制，特别是 MSCs 的免疫抑制作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c05/6985662/ab0d8f1027a2/CPR-53-e12712-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c05/6985662/e9c208d736db/CPR-53-e12712-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c05/6985662/a66085100aed/CPR-53-e12712-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c05/6985662/ab0d8f1027a2/CPR-53-e12712-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c05/6985662/e9c208d736db/CPR-53-e12712-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c05/6985662/a66085100aed/CPR-53-e12712-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c05/6985662/ab0d8f1027a2/CPR-53-e12712-g003.jpg

相似文献

[1]
Immune modulation by mesenchymal stem cells.

Cell Prolif. 2019-11-15

[2]
New concepts on the immune modulation mediated by mesenchymal stem cells.

Stem Cell Res Ther. 2010-11-11

[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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Ann N Y Acad Sci. 2017-7-12

[9]
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Exp Cell Res. 2006-7-15

[10]
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引用本文的文献

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Front Immunol. 2025-8-20

[2]
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Vet Res Commun. 2025-8-28

[3]
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Front Neurol. 2025-8-8

[4]
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Stem Cell Res Ther. 2025-8-26

[5]
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Cancer Immunol Immunother. 2025-8-23

[6]
Advances in Stem Cell Therapies for Ocular Diseases: Progress in Clinical Trials and Future Perspectives.

Stem Cell Rev Rep. 2025-8-20

[7]
Bone marrow-derived mesenchymal stromal cells in necrotizing enterocolitis treatment: a narrative review.

Front Pediatr. 2025-7-31

[8]
In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy.

Exp Hematol Oncol. 2025-8-10

[9]
Mesenchymal Stem Cells Reduce Inflammation in a Mouse Model of Lyme Arthritis.

Stem Cells Int. 2025-7-28

[10]
Healing of tendon-related diseases: insights from macrophage regulation.

Mil Med Res. 2025-8-4

本文引用的文献

[1]
Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2.

Nature. 2019-4-3

[2]
Innate Lymphoid Cells: 10 Years On.

Cell. 2018-8-23

[3]
Mesenchymal Stromal Cells Stimulate the Proliferation and IL-22 Production of Group 3 Innate Lymphoid Cells.

J Immunol. 2018-7-6

[4]
Peripheral PDGFRαgp38 mesenchymal cells support the differentiation of fetal liver-derived ILC2.

J Exp Med. 2018-5-4

[5]
Mesenchymal stem cells protect from acute liver injury by attenuating hepatotoxicity of liver natural killer T cells in an inducible nitric oxide synthase- and indoleamine 2,3-dioxygenase-dependent manner.

J Tissue Eng Regen Med. 2017-8-2

[6]
Mesenchymal stem cells attenuate acute liver injury by altering ratio between interleukin 17 producing and regulatory natural killer T cells.

Liver Transpl. 2017-8

[7]
Bone Marrow-Derived Mesenchymal Stem Cells-Mediated Protection Against Organ Dysfunction in Disseminated Intravascular Coagulation Is Associated With Peripheral Immune Responses.

J Cell Biochem. 2017-10

[8]
Mesenchymal stem cells ameliorate B-cell-mediated immune responses and increase IL-10-expressing regulatory B cells in an EBI3-dependent manner.

Cell Mol Immunol. 2017-1-2

[9]
Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis.

J Clin Invest. 2016-11-1

[10]
Mesenchymal Stromal Cell Secretion of Programmed Death-1 Ligands Regulates T Cell Mediated Immunosuppression.

Stem Cells. 2017-3

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