Center for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, 1430 Tulane Ave, SL-99, New Orleans, LA 70112, USA.
Stem Cell Res Ther. 2010 Nov 11;1(5):34. doi: 10.1186/scrt34.
Mesenchymal stem cells (MSCs) are the nonhematopoietic multipotent progenitor cells found in various adult tissues. They are characterized by their ease of isolation and their rapid growth in vitro while maintaining their differentiation potential, allowing for extensive expansion in culture that yields large quantities suitable for therapeutic use. This article reviews the immunomodulatory activities associated with MSCs. Numerous studies have demonstrated that MSCs are potently immunosuppressive in vitro and in vivo. However, this article presents a new paradigm in MSC biology, in which MSCs, at least in vitro, can undergo polarization into either a pro-inflammatory or an immunosuppressive phenotype.
间充质干细胞（MSCs）是存在于各种成人组织中的非造血多能祖细胞。它们的特点是易于分离，在体外快速生长，同时保持其分化潜能，从而可以在培养中进行广泛扩增，获得大量适合治疗用途的细胞。本文综述了与间充质干细胞相关的免疫调节活性。许多研究表明，间充质干细胞在体外和体内具有强大的免疫抑制作用。然而，本文提出了间充质干细胞生物学中的一个新范例，即在体外，间充质干细胞至少可以向促炎或免疫抑制表型极化。
