钽催化氨基酸同系物的酰胺化反应。
Tantalum-Catalyzed Amidation of Amino Acid Homologues.
机构信息
Molecular Catalyst Research Center , Chubu University , 1200 Matsumoto-cho , Kasugai , Aichi 487-8501 , Japan.
出版信息
J Am Chem Soc. 2019 Dec 4;141(48):18926-18931. doi: 10.1021/jacs.9b08415. Epub 2019 Nov 19.
PMID:31730340
Abstract
A tantalum-catalyzed solvent-free approach for the construction of amide bonds with 1-(trimethylsilyl)imidazole is developed, and the mild reaction conditions are applicable to a wide variety of electrophilic amino acid homologues. This approach delivers a new class of peptides in high yields without any epimerization.
摘要
发展了一种钽催化的无溶剂方法，使用 1-(三甲基甲硅烷基)咪唑构建酰胺键，温和的反应条件适用于多种亲电氨基酸同系物。该方法以高产率提供了一类新型肽，没有任何差向异构化。
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