铜催化卤代咪唑的酰胺化反应
Cu-catalyzed amidation of halogenated imidazoles.
作者信息
Wang Mo, Zhang Zhenfeng, Xie Fang, Zhang Wanbin
机构信息
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China.
出版信息
Chem Commun (Camb). 2014 Mar 25;50(24):3163-5. doi: 10.1039/c3cc49107b. Epub 2014 Feb 3.
PMID:24488206
Abstract
An efficient methodology involving the Cu-catalyzed amidation of halogenated imidazoles has been successfully developed. The amidated product of 5-bromo-1-alkylimidazole was further applied to the synthesis of a new chiral imidazole nucleophilic catalyst for the kinetic resolution of secondary alcohols.
摘要
一种涉及铜催化卤代咪唑酰胺化反应的高效方法已成功开发出来。5-溴-1-烷基咪唑的酰胺化产物进一步应用于新型手性咪唑亲核催化剂的合成，用于仲醇的动力学拆分。
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