Ammirati M, Ciric I, Rabin E
Division of Neurosurgery, Northwestern University Medical School, Chicago.
Microsurgery. 1988;9(2):78-81. doi: 10.1002/micr.1920090204.
Aneurysms were produced on the common carotid artery of rats by milliwatt CO2 laser welding of an adventitia patch over a hole. Sixty-nine animals were operated on. Aneurysms were present in 35 animals (51%), 7 of which ruptured spontaneously. The time to aneurysm formation was 1 week or longer. The adventitia patch aneurysm model has features (reliability, minimal vessel manipulation, histology similar to human berry aneurysm, and spontaneous bleeding tendency) that make it theoretically suitable for the induction of intracranial aneurysms in experimental animals. The microsurgical skills required to create and dissect the aneurysm make our experimental aneurysm useful as a teaching model in the development of microneurovascular surgery skills.
通过用毫瓦级二氧化碳激光将一块外膜补片焊接在大鼠颈总动脉的一个孔洞上制造动脉瘤。对69只动物进行了手术。35只动物（51%）出现了动脉瘤，其中7只自发破裂。动脉瘤形成的时间为1周或更长时间。外膜补片动脉瘤模型具有一些特点（可靠性、对血管的操作极少、组织学与人类浆果状动脉瘤相似以及有自发出血倾向），这些特点使其在理论上适合于在实验动物中诱发颅内动脉瘤。创建和解剖动脉瘤所需的显微外科技术使我们的实验性动脉瘤成为显微神经血管外科技术发展中的一种有用教学模型。
