Quigley M R, Heiferman K, Kwaan H C, Vidovich D, Nora P, Cerullo L J
J Neurosurg. 1987 Aug;67(2):284-7. doi: 10.3171/jns.1987.67.2.0284.
Laser-assisted vascular anastomosis (LAVA) is associated with a significant aneurysm problem when it is applied to small arteries. The etiology of this phenomenon was investigated by creating arteriotomies of different lengths and orientation in the rat carotid artery and sealing them with the milliwatt CO2 laser. It was found that increasing the arteriotomy length from 0.5 to 1.0 mm significantly raised aneurysm occurrence (4/17 vs. 25/28, chi-square: p less than 0.001) regardless of orientation. Systemic hypertension (systolic blood pressure greater than or equal to 170 mm Hg) also significantly affected the aneurysm rate among the 0.5-mm arteriotomy group, raising aneurysm occurrence from 23.5% (4/17) to 100% (14/14) (p less than 0.001). Assuming that the stay-sutures used for LAVA's act as rigid supports, the rate of aneurysm occurrence must be related to the distance between sutures. This phenomenon has been exploited to create a reliable aneurysm model.
激光辅助血管吻合术（LAVA）应用于小动脉时会出现严重的动脉瘤问题。通过在大鼠颈动脉上制作不同长度和方向的动脉切口并用毫瓦级二氧化碳激光进行封闭，对这一现象的病因进行了研究。结果发现，无论方向如何，将动脉切口长度从0.5毫米增加到1.0毫米都会显著提高动脉瘤的发生率（4/17 vs. 25/28，卡方检验：p小于0.001）。全身性高血压（收缩压大于或等于170毫米汞柱）在0.5毫米动脉切口组中也显著影响动脉瘤发生率，使动脉瘤发生率从23.5%（4/17）升至100%（14/14）（p小于0.001）。假设用于LAVA的留置缝线起到刚性支撑作用，动脉瘤发生率必定与缝线间距有关。这一现象已被用于创建可靠的动脉瘤模型。
