绿皮香蕉（Musa sp.）中的抗性淀粉可减轻高脂肪饮食诱导肥胖小鼠的非酒精性脂肪肝堆积，并增加短链脂肪酸的生成。
Resistant starch from green banana (Musa sp.) attenuates non-alcoholic fat liver accumulation and increases short-chain fatty acids production in high-fat diet-induced obesity in mice.
机构信息
Laboratory for Studies of Interactions Between Nutrition and Genetics, LEING, Department of Basic and Experimental Nutrition, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
出版信息
Int J Biol Macromol. 2020 Feb 15;145:1066-1072. doi: 10.1016/j.ijbiomac.2019.09.199. Epub 2019 Nov 13.
This study aimed to investigate the effect of resistant starch from green banana (GB) on steatosis and short-chain fatty acid (SCFAs) production in high fat diet-induced obesity in mice. High-fat green banana group (HFB) exhibited lower gains in BM (body mass; -6%; P < 0.01) compared with High-fat diet group (HF). Additionally, HFB mice showed reduction in liver steatosis (-28%, P < 0.01) with reduction of 93% in hepatic triacylglycerol (P < 0.01) compared to HF-diet-fed mice. In addition, the protein abundance of AMPKp/AMPK, HMGCoA-r and FAS were downregulated in livers of HFB mice (P < 0.01), relatively to the HF-diet-fed mice. ABCG8 and ABCG5 were up-regulated in HFB group compared to HF group (P < 0.01). Furthermore, the HFB fed-mice produced the highest amount of SCFAs (p < 0.05) compared to its counterpart HFD. In conclusion, we demonstrated that resistant starch from GB improved metabolic parameters by modulating the expression of key proteins involved in liver lipid metabolism.
本研究旨在探讨绿香蕉（GB）抗性淀粉对高脂饮食诱导肥胖小鼠脂肪变性和短链脂肪酸（SCFAs）生成的影响。高脂肪绿香蕉组（HFB）与高脂肪饮食组（HF）相比，体重增加明显减少（-6%；P<0.01）。此外，与 HF 饮食喂养的小鼠相比，HFB 小鼠肝脏脂肪变性减少（-28%；P<0.01），肝三酰甘油减少 93%（P<0.01）。此外，HFB 小鼠肝脏中 AMPKp/AMPK、HMGCoA-r 和 FAS 的蛋白丰度下调（P<0.01），与 HF 饮食喂养的小鼠相比。ABCG8 和 ABCG5 在 HFB 组中上调，与 HF 组相比（P<0.01）。此外，与 HFD 相比，HFB 喂养的小鼠产生的 SCFAs 最多（p<0.05）。总之，我们证明了 GB 中的抗性淀粉通过调节参与肝脏脂质代谢的关键蛋白的表达来改善代谢参数。
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