Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao 266021, China.
Oxid Med Cell Longev. 2022 May 24;2022:4330681. doi: 10.1155/2022/4330681. eCollection 2022.
The dietary flavonoid quercetin is ubiquitously distributed in fruits, vegetables, and medicinal herbs. Quercetin has been a focal point in recent years due to its versatile health-promoting benefits and high pharmacological values. It has well documented that quercetin exerts anticancer actions by inhibiting cell proliferation, inducing apoptosis, and retarding the invasion and metastasis of cancer cells. However, the exact mechanism of quercetin-mediated cancer chemoprevention is still not fully understood. With the advances in high-throughput sequencing technologies, the intricate oncogenic signaling networks have been gradually characterized. Increasing evidence on the close association between noncoding RNA (ncRNAs) and cancer etiopathogenesis emphasizes the potential of ncRNAs as promising molecular targets for cancer treatment. Available experimental studies indicate that quercetin can dominate multiple cancer-associated ncRNAs, hence repressing carcinogenesis and cancer development. Thus, modulation of ncRNAs serves as a key mechanism responsible for the anticancer effects of quercetin. In this review, we focus on the chemopreventive effects of quercetin on cancer pathogenesis by targeting cancer-relevant ncRNAs, supporting the viewpoint that quercetin holds promise as a drug candidate for cancer chemoprevention and chemotherapy. An in-depth comprehension of the interplay between quercetin and ncRNAs in the inhibition of cancer development and progression will raise the possibility of developing this bioactive compound as an anticancer agent that could be highly efficacious and safe in clinical practice.
膳食类黄酮槲皮素广泛存在于水果、蔬菜和草药中。由于其具有多种促进健康的益处和高药理学价值，槲皮素近年来成为研究焦点。已有充分的证据表明，槲皮素通过抑制细胞增殖、诱导细胞凋亡和延缓癌细胞的侵袭和转移来发挥抗癌作用。然而，槲皮素介导的癌症化学预防的确切机制仍不完全清楚。随着高通量测序技术的进步，错综复杂的致癌信号网络逐渐得到了描述。越来越多的证据表明非编码 RNA（ncRNA）与癌症发病机制之间存在密切关联，这强调了 ncRNA 作为癌症治疗有前途的分子靶点的潜力。现有的实验研究表明，槲皮素可以调控多种与癌症相关的 ncRNA，从而抑制致癌作用和癌症发展。因此，ncRNA 的调控是槲皮素发挥抗癌作用的关键机制之一。在这篇综述中，我们重点讨论了槲皮素通过靶向与癌症相关的 ncRNA 对癌症发病机制的化学预防作用，支持了槲皮素作为癌症化学预防和化疗候选药物的观点。深入了解槲皮素与 ncRNA 之间在抑制癌症发展和进展中的相互作用，将有可能开发出这种具有生物活性的化合物，作为一种在临床实践中具有高效和安全性的抗癌药物。
