Department of Bioresources and Food Science, Konkuk University, Seoul, 05029, South Korea.
Department of Pharmacy, Abdul Wali Khan University, Mardan, 23200, Pakistan.
Pharmacol Res. 2019 Sep;147:104346. doi: 10.1016/j.phrs.2019.104346. Epub 2019 Jul 8.
A growing number of evidences from clinical and preclinical studies have shown that dysregulation of microRNA (miRNA) function contributes to the progression of cancer and thus miRNA can be an effective target in therapy. Dietary phytochemicals, such as quercetin, are natural products that have potential anti-cancer properties due to their proven antioxidant, anti-inflammatory, and anti-proliferative effects. Available experimental studies indicate that quercetin could modulate multiple cancer-relevant miRNAs including let-7, miR-21, miR-146a and miR-155, thereby inhibiting cancer initiation and development. This paper reviews the data supporting the use of quercetin for miRNA-mediated chemopreventive and therapeutic strategies in various cancers, with the aim to comprehensively understand its health-promoting benefits and pharmacological potential. Integration of technology platforms for miRNAs biomarker and drug discovery is also presented.
越来越多的临床和临床前研究证据表明，miRNA 功能失调导致癌症的进展，因此 miRNA 可以成为治疗的有效靶点。膳食植物化学物质，如槲皮素，是具有潜在抗癌特性的天然产物，因为它们具有已被证实的抗氧化、抗炎和抗增殖作用。现有的实验研究表明，槲皮素可以调节多种与癌症相关的 miRNA，包括 let-7、miR-21、miR-146a 和 miR-155，从而抑制癌症的发生和发展。本文综述了支持使用槲皮素进行 miRNA 介导的化学预防和治疗各种癌症的策略的数据，旨在全面了解其促进健康的益处和药理学潜力。还介绍了 miRNA 生物标志物和药物发现技术平台的整合。
