滑液素在脓毒症中的治疗作用及作为潜在生物标志物的研究进展。
Lubricin as a Therapeutic and Potential Biomarker in Sepsis.
机构信息
Department of Emergency Medicine, Alpert Medical School, Brown University, 222 Richmond Street, Providence, RI 02903, USA; Department of Emergency Medicine, Research Laboratory, Rhode Island Hospital, 1 Hoppin Street, CORO West, Room 4.303, Providence, RI 02903, USA.
Department of Emergency Medicine, Alpert Medical School, Brown University, 222 Richmond Street, Providence, RI 02903, USA; Department of Emergency Medicine, Research Laboratory, Rhode Island Hospital, 1 Hoppin Street, CORO West, Room 4.303, Providence, RI 02903, USA.
出版信息
Crit Care Clin. 2020 Jan;36(1):55-67. doi: 10.1016/j.ccc.2019.08.005. Epub 2019 Oct 21.
Abstract
Proteoglycan 4 (or lubricin), a mucin-like glycoprotein, was originally classified as a lubricating substance within diarthrodial joints. More recently, lubricin has been found in other tissues and has been implicated in 2 inflammatory pathways within the cell, via the Toll-like receptors (TLRs) and CD44. Lubricin is an antagonist of TLR2 and TLR4, and appears to enter cells via the CD44 receptor. Because of lubricin's action on these receptors, downstream processes of inflammation are halted, thereby preventing release of cytokines (a hallmark of inflammation and sepsis) from the cell, indicating lubricin's role as a biomarker and possible therapeutic for sepsis.
摘要
蛋白聚糖 4（或黏蛋白样糖蛋白）最初被归类为滑液关节中的润滑物质。最近，人们发现黏蛋白存在于其他组织中，并通过 Toll 样受体 (TLRs) 和 CD44 参与细胞内的 2 种炎症途径。黏蛋白是 TLR2 和 TLR4 的拮抗剂，似乎通过 CD44 受体进入细胞。由于黏蛋白对这些受体的作用，炎症的下游过程被阻止，从而防止细胞释放细胞因子（炎症和脓毒症的标志），表明黏蛋白作为生物标志物和脓毒症的潜在治疗方法的作用。
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