Borg Anouk, Jaunmuktane Zane, Dorward Neil
Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London Hospitals, London, UK; UCL Queen Square Institute of Neurology, London, UK.
World Neurosurg. 2020 Feb;134:e968-e978. doi: 10.1016/j.wneu.2019.11.043. Epub 2019 Nov 14.
To evaluate and understand the clinical behavior and radiologic correlates of tumors originating from the posterior pituitary gland. To review the management strategy for these rare tumors and add to the limited existing literature.
Retrospective review of 8 cases (5 pituicytomas, 2 spindle cell oncocytomas, and 1 granular cell tumor) managed at our institution between 2004 and 2019. The patients' clinical course, histologic features, and radiologic findings were reviewed. Their management and long-term follow-up is presented and compared with the literature.
Long-term follow-up ranged from 1 to 9 years. There was 1 recurrence in a patient with spindle cell oncocytoma, and this was treated with radiotherapy. The endoscopically managed cases resulted in complete tumor excision with no recurrence.
Epidemiologic data on primary tumors of the neurohypophysis is limited because of the rarity of these tumors. This study adds to the literature that these tumors behave as World Health Organization grade I tumors, although close follow-up is recommended as a few cases have shown recurrence. The endoscopic approach resulted in better gross total tumor resection rate in this series.
评估并了解源自垂体后叶的肿瘤的临床行为及影像学特征。回顾这些罕见肿瘤的治疗策略，并补充现有有限的文献资料。
对2004年至2019年间在我院接受治疗的8例患者（5例垂体细胞瘤、2例梭形细胞嗜酸细胞瘤和1例颗粒细胞瘤）进行回顾性分析。回顾患者的临床病程、组织学特征和影像学表现。介绍他们的治疗情况和长期随访结果，并与文献进行比较。
长期随访时间为1至9年。1例梭形细胞嗜酸细胞瘤患者出现复发，接受了放射治疗。经内镜治疗的病例实现了肿瘤完全切除，无复发。
由于这些肿瘤罕见，关于神经垂体原发性肿瘤的流行病学数据有限。本研究补充了文献资料，表明这些肿瘤属于世界卫生组织I级肿瘤，不过鉴于少数病例出现复发，建议密切随访。在本系列研究中，内镜治疗方法实现了更高的肿瘤全切除率。
