Effects of Cognitive Rehabilitation on Cognition, Apathy, Quality of Life, and Subjective Complaints in the Elderly: A Randomized Controlled Trial.

OBJECTIVE

To determine the efficacy of a new-generation integrative cognitive rehabilitation (CR) program (Rehacop) on cognition, clinical symptoms, quality of life (QoL), and subjective complaints in the elderly.

DESIGN

A randomized controlled trial study with a cohort of elderly people over 55 years of age.

SETTING

Communities of the Basque Country (Spain).

PARTICIPANTS

A total of 124 elderly participants (aged 79.00 ± 8.85 years) were randomized in the Rehacop group (RG) (n = 62) and control group (CG) (n = 62).

INTERVENTION

The RG attended 39 CR sessions for 3 months (3 sessions/week, 60-minute/session) with the Rehacop program. The CG performed occupational tasks with the same frequency and duration as the RG.

METHODS

Participants underwent a neuropsychological assessment at baseline and post-treatment which included cognitive, clinical, and functional tests. In addition, participants and their formal caregivers completed a subjective complaints questionnaire. The data were analyzed according to the intention to treat analysis and with participants who completed the study. This study was registered at clinicaltrials.gov (NCT03435029).

RESULTS

The RG showed significant improvements compared to the CG in neurocognition (ANCOVA timexgroup interaction effect size (η)=0.05, 90% confidence interval (CI) = 0.00-0.12). The RG also reduced apathy (η=0.06, 90% CI = 0.01-0.15) and participants' subjective complaints (η=0.11, 90% CI = 0.03-0.21) and improved QoL (η=0.08, 90% CI = 0.01-0.17).

CONCLUSIONS

Participants who attended the intervention improved their cognition, QoL, and reduced apathy and subjective complaints after treatment. These findings provide a new understanding of the benefits of CR in the elderly.