Department of Biochemistry, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 620 024, Tamil Nadu, India; Ohio Agricultural Research and Development Center, The Ohio State University, 1680 Madison Avenue, Wooster, OH, 44691, United States.
Regional Forensic Science Laboratory, Tiruchirappalli, Tamil Nadu, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2020 Mar 5;228:117673. doi: 10.1016/j.saa.2019.117673. Epub 2019 Oct 19.
Polymeric nanocomposites have gained extensive attention in modern nanotechnology by reason of its design, flexibility, sole applications and lower life cycle costs. Preparation of composites using spreading of inorganic metal nanoparticles in organic polymeric matrices has plenty of scope and applications in the biomedical field. Poly-D,l-lactide-co-glycolide (PLGA) is an appreciated polymer for composites preparation because of its non-toxic and promising biodistribution. The consideration of metal nanoparticles has extended rapidly with the presence of new nanocomposites into a range of products and technologies. Compared to bulk materials the synthesized metal nanoparticles have unique character and biomedical uses due to its shape, size, and huge surface to volume ratio. Among different inorganic metal nanoparticles, silver nanoparticles (Ag NPs) have dominated in the biomedical field owing to its diverse potential applications including imaging, sensor, diagnosis and disease treatment. Further, medicinal plant extract mediated Ag NPs shown superior advantages and its antimicrobial based wound healing prospective has been established. However, not much information on plant extract mediated Ag NPs integrated PLGA nanocomposites wound healing applications. In the present review, we discussed necessity, preparation, characterization and antimicrobial based wound healing mechanism of incorporated plant extract mediated silver/PLGA nanocomposites.
高分子纳米复合材料因其设计、灵活性、独特的应用和较低的生命周期成本，在现代纳米技术中引起了广泛关注。将无机金属纳米粒子在有机高分子基体中扩散制备复合材料在生物医学领域有广泛的应用前景。聚（D，L-丙交酯-co-乙交酯）（PLGA）是一种备受关注的复合材料制备用聚合物，因为它具有无毒和良好的生物分布。由于新型纳米复合材料具有独特的性质和生物医学用途，包括其形状、尺寸和巨大的表面积与体积比，金属纳米粒子的考虑已经迅速扩展到一系列产品和技术中。与块状材料相比，合成的金属纳米粒子具有独特的性质和生物医学用途，因为其形状、尺寸和巨大的表面积与体积比。在不同的无机金属纳米粒子中，银纳米粒子（Ag NPs）在生物医学领域占据主导地位，因为它具有多种潜在的应用，包括成像、传感器、诊断和疾病治疗。此外，药用植物提取物介导的 Ag NPs 显示出优越的优势，其基于抗菌的伤口愈合前景已经建立。然而，关于植物提取物介导的 Ag NPs 与 PLGA 纳米复合材料的伤口愈合应用的信息并不多。在本综述中，我们讨论了包含植物提取物介导的银/PLGA 纳米复合材料的必要性、制备、表征和基于抗菌的伤口愈合机制。
