Marchenko S M, Obukhov A G, Volkova T M
Neirofiziologiia. 1988;20(3):410-2.
Action of natural ribonucleotides on ATP receptors of rat nodose ganglion has been studied. Nucleotides containing guanine, uracil or hypoxanthine residues as nitrogen base are competitive blockers of the receptors. Their pharmacological activity decreases along with reduction of the polyphosphate chain length. The most efficient blocker among them is guanosine-5'-triphosphate. Cytidine nucleotides as well as adenine ones are agonists of ATP receptors, if their polyphosphate chain contains two or three phosphate residues and are blockers, if it contains only one residue.
已对天然核糖核苷酸对大鼠结状神经节ATP受体的作用进行了研究。含有鸟嘌呤、尿嘧啶或次黄嘌呤残基作为氮碱基的核苷酸是该受体的竞争性阻断剂。它们的药理活性随着多磷酸链长度的缩短而降低。其中最有效的阻断剂是5'-三磷酸鸟苷。如果胞苷核苷酸和腺嘌呤核苷酸的多磷酸链含有两个或三个磷酸残基，则它们是ATP受体的激动剂；如果只含有一个磷酸残基，则它们是阻断剂。
