Department of Medical Biology and Biochemistry, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Bydgoszcz, Karłowicza 24 85-092, Poland.
Specialized in Family Medicine Clinic Dr. Dariusz Górecki and Partners, Przesmyk 2/4 87-100 Toruń, Poland.
Dis Markers. 2019 Oct 15;2019:6178017. doi: 10.1155/2019/6178017. eCollection 2019.
Obesity has serious consequences such as the onset of metabolic syndrome, type 2 diabetes, atherosclerosis, or cardiovascular complications. The aim of this study was to evaluate the levels of paraoxonase 1 (PON1), lectin-like oxidized LDL receptor-1 (LOX-1), antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)), and lipid peroxidation processes in the course of obesity.
28 men took part in the experiment. Fourteen of them were obese; the control group consisted of 14 physically active men without obesity features. The concentrations of malondialdehyde (MDA), PON1, LOX-1, and tumor necrosis factor (TNF) as well as the activities of erythrocytic SOD, CAT, and GPx were determined in the study.
Statistically significant higher MDA, LOX-1, and TNF levels were observed in obese subjects. Conversely, lower concentrations of PON1 in obese men were found.
An imbalance in oxidation-reduction processes accompanies obesity. Moreover, inflammatory cytokines and atherosclerotic complications are involved in the obesity process. The obtained results suggest that the studied parameters may be independent prognostic markers preceding the development of cardiovascular and metabolic complications in people afflicted with type II obesity.
肥胖会导致严重后果，如代谢综合征、2 型糖尿病、动脉粥样硬化或心血管并发症的发生。本研究旨在评估肥胖过程中对氧磷酶 1（PON1）、凝集素样氧化型 LDL 受体-1（LOX-1）、抗氧化酶（超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx））以及脂质过氧化过程中的水平。
28 名男性参与了实验。其中 14 人肥胖，对照组由 14 名没有肥胖特征的活跃男性组成。研究中测定了丙二醛（MDA）、PON1、LOX-1 和肿瘤坏死因子（TNF）的浓度以及红细胞 SOD、CAT 和 GPx 的活性。
肥胖组的 MDA、LOX-1 和 TNF 水平显著升高。相反，肥胖男性的 PON1 浓度较低。
氧化还原过程失衡伴随着肥胖。此外，炎症细胞因子和动脉粥样硬化并发症参与了肥胖过程。研究结果表明，所研究的参数可能是 II 型肥胖患者发生心血管和代谢并发症之前的独立预后标志物。
