Dept of Psychology, B326 Gottwald Science Center, University of Richmond, VA 23173, United States.
Dept of Psychology, University of Massachusetts-Boston, 100 Morrissey Blvd., Boston, MA 00252, United States.
Front Neuroendocrinol. 2020 Jan;56:100802. doi: 10.1016/j.yfrne.2019.100802. Epub 2019 Nov 15.
The ability to adapt to stressful circumstances, known as emotional resilience, is a key factor in the maintenance of mental health. Several individual biomarkers of the stress response (e.g., corticosterone) that influence an animal's position along the continuum that ranges from adaptive allostasis to maladaptive allostatic load have been identified. Extending beyond specific biomarkers of stress responses, however, it is also important to consider stress-related responses relative to other relevant responses for a thorough understanding of the underpinnings of adaptive allostasis. In this review, behavioral, neurobiological, developmental and genomic variables are considered in the context of emotional resilience [e.g., explore/exploit behavioral tendencies; DHEA/CORT ratios and relative proportions of protein-coding/nonprotein-coding (transposable) genomic elements]. As complex and multifaceted relationships between pertinent allostasis biomediators are identified, translational applications for optimal resilience are more likely to emerge as effective therapeutic strategies.
适应紧张环境的能力，即情绪弹性，是维持心理健康的关键因素。已经确定了几种影响动物在从适应性适应到适应性负荷的适应度连续体上位置的应激反应的个体生物标志物（例如皮质酮）。然而，超越应激反应的具体生物标志物，考虑与其他相关反应相关的应激反应对于全面了解适应性适应的基础也很重要。在这篇综述中，行为、神经生物学、发育和基因组变量在情绪弹性的背景下进行了考虑[例如，探索/利用行为倾向；DHEA/CORT 比值和蛋白质编码/非蛋白质编码（转座）基因组元件的相对比例]。随着确定相关适应度生物介质之间复杂而多方面的关系，作为有效治疗策略的最佳弹性的转化应用更有可能出现。
