Institute of Research & Development, Gujarat Forensic Sciences University, Sector 9, Near Police Bhawan, Gandhinagar 382007, Gujarat, India.
Loyola Center for Research & Development-Xavier Research Foundation, GFSU recognized Research Center, Navrangpura, Ahmedabad 380009, India.
Adv Colloid Interface Sci. 2020 Jan;275:102063. doi: 10.1016/j.cis.2019.102063. Epub 2019 Nov 9.
In recent times, incorporation of Halloysite Nanotubes (HNTs) with various antimicrobial agents as interfacial materials between these nanotubes and pathogenic microorganisms, for the development of antimicrobial nanocomposites with enhanced antimicrobial activities has gained researcher's interest. The main benefits given by HNT to these nanocomposites include enhanced thermal and mechanical stability of the antimicrobial nanocomposites and also prolong durability and release of the antimicrobial agents in a sustained manner. The exceptional structure of these aluminosilicate minerals based nanotubes (hollow tubular lumen with huge surface area) and oppositely charged surface molecules assist in attaching various molecules on both, the internal surface as well as on the outer surface of these nanotubes. Other advantages of these clay-based minerals are their biocompatibility, non-toxicity, eco-friendly nature and their natural availability with affordable price, which also contribute in selecting them as supporting material for biological applications. Therefore, these clay-based nanotubes have been recently used for developing various antimicrobial nanocomposites. In this review, various antimicrobial nanocomposites developed through incorporation of HNT with myriad antimicrobial agents such as nanoparticles, metal ions, antibiotics, essential oils, biopolymers, phenolic compounds, surfactants and food preservatives as an interface between these nanotubes and microorganisms have been discussed. These antimicrobial nanocomposites could be synthesized in different forms (powder, film, nanocapsule and adhesive) which can be applicable in various fields such as food packaging, water decontamination, waste water management, healing of wounds, antimicrobial agents for surfaces, orthopedics and for the treatment of microbial infections.
近年来，将埃洛石纳米管（HNTs）与各种抗菌剂结合作为这些纳米管和致病微生物之间的界面材料，以开发具有增强抗菌活性的抗菌纳米复合材料，引起了研究人员的兴趣。HNT 赋予这些纳米复合材料的主要好处包括增强抗菌纳米复合材料的热稳定性和机械稳定性，以及以可持续的方式延长抗菌剂的耐久性和释放。这些基于铝硅酸盐矿物的纳米管（具有巨大表面积的中空管状腔）的特殊结构和带相反电荷的表面分子有助于将各种分子附着在这些纳米管的内部表面和外表面上。这些粘土基矿物的其他优点是它们的生物相容性、无毒、环保性质以及它们的天然可用性和可承受的价格，这也有助于选择它们作为生物应用的支撑材料。因此，这些基于粘土的纳米管最近已被用于开发各种抗菌纳米复合材料。在这篇综述中，讨论了通过将 HNT 与各种抗菌剂（如纳米颗粒、金属离子、抗生素、精油、生物聚合物、酚类化合物、表面活性剂和食品防腐剂）结合作为这些纳米管和微生物之间的界面，开发的各种抗菌纳米复合材料。这些抗菌纳米复合材料可以以不同的形式（粉末、薄膜、纳米胶囊和粘合剂）合成，可应用于食品包装、水净化、废水处理、伤口愈合、表面抗菌剂、矫形和治疗微生物感染等各个领域。
