Walters T R
Am J Pediatr Hematol Oncol. 1979 Fall;1(3):285-7. doi: 10.1097/00043426-197923000-00014.
The occurrence of de novo cancer in renal transplant patients who have received immunosuppressive therapy has been noted. An increased incidence of second primary neoplasm (SPN) has been reported in adults with various forms of cancer. The incidence of SPN in childhood cancer is lower. Successful therapy in several childhood cancers has resulted in prolonged disease-free survival time with the opportunity for longer patient-years of observation. The development of a SPN, an astrocytoma, in a child with continuous complete remission for more than 6 years is reported. The incidence of SPN in childhood cancer needs to be established.
已注意到接受免疫抑制治疗的肾移植患者出现新发癌症的情况。据报道，患有各种癌症的成年人中第二原发性肿瘤（SPN）的发病率有所增加。儿童癌症中SPN的发病率较低。几种儿童癌症的成功治疗导致无病生存期延长，从而有机会进行更长时间的患者年观察。本文报告了一名儿童在持续完全缓解超过6年后发生SPN（星形细胞瘤）的情况。儿童癌症中SPN的发病率有待确定。
