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Cells. 2018 Aug 7;7(8):96. doi: 10.3390/cells7080096.
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PP2A Inhibits Cervical Cancer Cell Migration by Dephosphorylation of p-JNK, p-p38 and the p-ERK/MAPK Signaling Pathway.蛋白磷酸酶 2A 通过去磷酸化 JNK、p38 和 ERK/MAPK 信号通路抑制宫颈癌细胞迁移。
Curr Med Sci. 2018 Feb;38(1):115-123. doi: 10.1007/s11596-018-1854-9. Epub 2018 Mar 15.
4
Investigation of conjunctivochalasis histopathology with light and electron microscopy in patients with conjunctivochalasis in different locations.不同部位结膜松弛症患者结膜松弛症组织病理学的光镜及电镜研究
Int Ophthalmol. 2019 Jul;39(7):1491-1499. doi: 10.1007/s10792-018-0963-6. Epub 2018 Jul 10.
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Can J Ophthalmol. 2017 Jun;52(3):308-312. doi: 10.1016/j.jcjo.2016.11.003. Epub 2016 Dec 23.
6
Expressions of matrix metalloproteinases 1 and 3 and their tissue inhibitors in the conjunctival tissue and fibroblasts cultured from conjunctivochalasis.结膜松弛症结膜组织及培养的成纤维细胞中基质金属蛋白酶1和3及其组织抑制剂的表达
Int J Ophthalmol. 2017 Apr 18;10(4):555-559. doi: 10.18240/ijo.2017.04.09. eCollection 2017.
7
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The treatment outcomes of crescent-shaped conjunctiva resection combined with conjunctiva sclera fixation for severe conjunctivochalasis.新月形结膜切除术联合结膜巩膜固定术治疗重度结膜松弛症的疗效
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High osmotic pressure increases reactive oxygen species generation in rabbit corneal epithelial cells by endoplasmic reticulum.高渗透压通过内质网增加兔角膜上皮细胞中的活性氧生成。
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丝裂原活化蛋白激酶（MAPK）信号通路在结膜松弛症中的表达

The expression of MAPK signaling pathways in conjunctivochalasis.

作者信息

Jia Yuan-Ling, Liu Xiao-Jing, Wen Hang, Zhan Yue-Ping, Xiang Min-Hong

机构信息

Department of Ophthalmology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China.

出版信息

Int J Ophthalmol. 2019 Nov 18;12(11):1801-1806. doi: 10.18240/ijo.2019.11.21. eCollection 2019.

DOI:10.18240/ijo.2019.11.21
PMID:31741872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6848865/
Abstract

This study investigated the potential role of MAPK signaling pathways in conjunctivochalasis (CCH). Twenty loose conjunctival biopsy samples from 20 CCH and 15 conjunctival biopsy samples from 15 normal controls (CON) were collected. The conjunctival fibroblasts were cultured . Immunofluorescence, ELISA, Western blot and reverse transcription-polymerase chain reaction (RT-PCR) were used. Our results showed that the expression of p-ERK, p-JNK, and p-p38 in CCH conjunctiva was significantly higher than that in CON group. The expression of p38 MAPK, JNK, and ERK proteins in CCH fibroblasts was significantly higher than that in CON group. The total expression of MAPK mRNA in CCH fibroblasts was significantly higher than that in CON group. The activated forms of p38 MAPK, JNK, and ERK proteins and mRNAs might up-regulate the expression of MMPs in CCH loose conjunctival tissue and fibroblasts, causing the degradation of collagen fibers and elastic fibers and promoting the occurrence of CCH. Our results deepen the understanding of CCH pathological mechanism.

摘要

本研究调查了丝裂原活化蛋白激酶（MAPK）信号通路在结膜松弛症（CCH）中的潜在作用。收集了来自20例CCH患者的20份结膜活检组织样本以及来自15例正常对照（CON）的15份结膜活检组织样本。对结膜成纤维细胞进行培养，并采用免疫荧光、酶联免疫吸附测定（ELISA）、蛋白质印迹法和逆转录-聚合酶链反应（RT-PCR）。我们的结果显示，CCH结膜中p-ERK、p-JNK和p-p38的表达显著高于CON组。CCH成纤维细胞中p38 MAPK、JNK和ERK蛋白的表达显著高于CON组。CCH成纤维细胞中MAPK mRNA的总表达显著高于CON组。p38 MAPK、JNK和ERK蛋白及mRNA的活化形式可能上调CCH疏松结膜组织和成纤维细胞中基质金属蛋白酶（MMPs）的表达，导致胶原纤维和弹性纤维降解，促进CCH的发生。我们的结果加深了对CCH病理机制的理解。