Hashemian Hesam, Mahbod Mirgholamreza, Amoli Fahimeh A, Kiarudi Mohammad Y, Jabbarvand Mahmoud, Kheirkhah Ahmad
Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Noor Ophthalmology Research Center, Noor Eye Hospital, Tehran, Iran.
J Ophthalmic Vis Res. 2016 Oct-Dec;11(4):345-349. doi: 10.4103/2008-322X.194068.
To evaluate the histopathologic changes in the conjunctiva of patients with conjunctivochalasis (CCh) compared to age-matched controls.
This cross-sectional, controlled study included 27 eyes of 27 patients with CCh and 16 eyes of 16 age-matched controls. A biopsy of the bulbar conjunctiva was performed along the temporal lower lid margin before cataract surgery in both groups. Histopathologic evaluation of the specimens was done with light microscopy using staining with hematoxylin/eosin, periodic acid Schiff, and van Gieson elastic stain. Various histopathologic features of the conjunctival epithelium and stroma were compared between the two groups.
The mean age of patients was 62.4 ± 6.9 years in the CCh group and 65.1 ± 6.3 years in the control group ( = 0.54). No significant differences were noted between the two groups in terms of conjunctival epithelial changes including papillomatosis, epithelial clefts, epithelial goblet cells, or infiltration of inflammatory cells. Mean thickness of the conjunctival stroma was 0.21 ± 0.08 mm in the CCh group and 0.26 ± 0.21 mm in the control group ( = 0.10). For the conjunctival stroma, there were no significant differences between the two groups in terms of elastosis, fibrosis, lymphangiectasia, or infiltration of inflammatory cells.
No noticeable differences were found in the histopathologic features by light microscopy between eyes with CCh and those of age-matched controls. Therefore, the primary pathology of CCh may not be within the conjunctiva itself. Instead, loose attachment of the conjunctiva to the underlying tissue may be the reason for the redundant folds in the bulbar conjunctiva.
评估结膜松弛症（CCh）患者与年龄匹配的对照组相比结膜的组织病理学变化。
这项横断面对照研究纳入了27例CCh患者的27只眼和16例年龄匹配的对照组的16只眼。两组均在白内障手术前沿颞下睑缘对球结膜进行活检。使用苏木精/伊红染色、过碘酸希夫染色和范吉森弹性染色，通过光学显微镜对标本进行组织病理学评估。比较两组结膜上皮和基质的各种组织病理学特征。
CCh组患者的平均年龄为62.4±6.9岁，对照组为65.1±6.3岁（P=0.54）。两组在结膜上皮变化方面无显著差异，包括乳头瘤病、上皮裂、上皮杯状细胞或炎性细胞浸润。CCh组结膜基质的平均厚度为0.21±0.08mm，对照组为0.26±0.21mm（P=0.10）。对于结膜基质，两组在弹性组织变性、纤维化、淋巴管扩张或炎性细胞浸润方面无显著差异。
通过光学显微镜观察，CCh患者的眼睛与年龄匹配的对照组在组织病理学特征上未发现明显差异。因此，CCh的主要病理改变可能不在结膜本身。相反，结膜与下方组织的松散附着可能是球结膜出现多余褶皱的原因。
