Department of Biology, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15784 Athens, Greece.
Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
Mar Drugs. 2019 Nov 16;17(11):646. doi: 10.3390/md17110646.
Red algae of the genus are known to biosynthesize and secrete an immense variety of secondary metabolites possessing a spectrum of biological activities against bacteria, invertebrates and mammalian cell lines. Following a rigorous cross-species screening process, herein we report the antifouling potential of 25 secondary metabolites derived from species of the genus , as well as the thorough evaluation of the ecotoxicity of selected metabolites against non-target marine arthropods and vertebrate cell lines. A number of these secondary metabolites exhibited potent antifouling activity and performed well in all screening tests. Our results show that perforenol () possesses similar antifouling activity with that already described for bromosphaerol, which is used herein as a benchmark.
红藻属的物种被已知能够生物合成和分泌大量具有多种生物活性的次生代谢产物，这些产物对细菌、无脊椎动物和哺乳动物细胞系具有抑制作用。经过严格的跨物种筛选过程，本文报告了 25 种源自该属物种的次生代谢产物的抗污损潜力，以及对选定代谢产物对非目标海洋节肢动物和脊椎动物细胞系的生态毒性的全面评估。这些次生代谢产物中的许多都表现出很强的抗污损活性，并且在所有筛选测试中表现良好。我们的结果表明，过氧菲（）具有与已描述的溴三亚醇相似的抗污损活性，溴三亚醇在此用作基准。
