Institute of Pharmacology & Toxicology, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Curr Neuropharmacol. 2020;18(6):464-484. doi: 10.2174/1570159X17666191118142314.
Epileptogenesis refers to the process in which a normal brain becomes epileptic, and is characterized by hypersynchronous spontaneous recurrent seizures involving a complex epileptogenic network. Current available pharmacological treatment of epilepsy is generally symptomatic in controlling seizures but is not disease-modifying in epileptogenesis. Cumulative evidence suggests that adult neurogenesis, specifically in the subgranular zone of the hippocampal dentate gyrus, is crucial in epileptogenesis. In this review, we describe the pathological changes that occur in adult neurogenesis in the epileptic brain and how adult neurogenesis is involved in epileptogenesis through different interventions. This is followed by a discussion of some of the molecular signaling pathways involved in regulating adult neurogenesis, which could be potential druggable targets for epileptogenesis. Finally, we provide perspectives on some possible research directions for future studies.
癫痫发生是指正常大脑转变为癫痫状态的过程，其特征为涉及复杂致痫网络的同步自发性反复发作。目前可用的癫痫药物治疗通常仅能控制发作，而不能改变癫痫发生。越来越多的证据表明，成人神经发生，特别是海马齿状回颗粒下区的神经发生，在癫痫发生中至关重要。在这篇综述中，我们描述了癫痫大脑中成人神经发生的病理变化，以及通过不同干预措施，成人神经发生如何参与癫痫发生。接下来讨论了一些参与调节成人神经发生的分子信号通路，这些通路可能是癫痫发生的潜在治疗靶点。最后，我们对未来研究的一些可能研究方向提供了一些看法。
