线粒体 DNA 作为炎症和疾病进展的主要驱动因素的新作用。
Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression.
机构信息
Laboratory of Molecular Virology and Immunology, College of Animal Science and Technology and College of Veterinary Medicine, Agricultural University of Hebei, Baoding, Hebei 071000, China.
Department of Immunology, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd., Dallas, TX 75390, USA.
出版信息
Trends Immunol. 2019 Dec;40(12):1120-1133. doi: 10.1016/j.it.2019.10.008. Epub 2019 Nov 16.
Inflammation benefits the host by promoting the elimination of invading pathogens and clearance of cellular debris after tissue injury. Inflammation also stimulates tissue repair and regeneration to restore homeostasis and organismal health. Emerging evidence suggests that mitochondrial DNA (mtDNA), the only form of non-nuclear DNA in eukaryotic cells, is a major activator of inflammation when leaked out from stressed mitochondria. Here, we review the current understanding on the role of mtDNA in innate immunity, discussing how dysregulated mtDNA metabolism can promote chronic inflammation and disease progression.
炎症通过促进入侵病原体的清除和组织损伤后细胞碎片的清除，使宿主受益。炎症还刺激组织修复和再生，以恢复体内平衡和机体健康。新出现的证据表明，线粒体 DNA（mtDNA）是真核细胞中唯一的非核 DNA 形式，当从应激线粒体中漏出时，它是炎症的主要激活物。在这里，我们回顾了 mtDNA 在先天免疫中的作用的现有认识，讨论了代谢失调的 mtDNA 如何促进慢性炎症和疾病进展。
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