青霉素预防实验室获得性钩端螺旋体病失败。
Failure of penicillin prophylaxis in laboratory acquired leptospirosis.
作者信息
Gilks C F, Lambert H P, Broughton E S, Baker C C
机构信息
St. George's Hospital, London, UK.
出版信息
Postgrad Med J. 1988 Mar;64(749):236-8. doi: 10.1136/pgmj.64.749.236.
Abstract
A laboratory technician developed leptospirosis following accidental inoculation, despite prompt administration of parenteral penicillin by an accepted regimen of post-exposure prophylaxis. Another technician was similarly exposed and was given doxycycline; no illness or serological conversion followed. The implications of these cases are discussed and recommendations made for post-exposure chemoprophylaxis with doxycycline.
摘要
一名实验室技术员在意外接种后感染了钩端螺旋体病，尽管按照公认的暴露后预防方案及时给予了肠胃外青霉素治疗。另一名技术员也受到了类似的暴露，并接受了强力霉素治疗；之后未出现疾病或血清学转化。本文讨论了这些病例的影响，并就使用强力霉素进行暴露后化学预防提出了建议。
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Typhoid fever: pathogenesis and immunologic control.伤寒热：发病机制与免疫控制
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