Münnich D, Lakatos M
Chemotherapy. 1976;22(6):372-80. doi: 10.1159/000221949.
Ampicillin (Semicillin) and Amoxycillin (Amoxil) have a strong leptospirocidal effect in vitro and also in vivo. We have tested these drugs on 28 patients suffering from Leptospira infection. The patients generally received per os 3 g Ampicillin (Semicillin) or 2 g Amoxycillin (Amoxil) per day over a period of 6 days. In the groups treated with Ampicillin and Amoxycillin the average durations of fever during the treatment were 1.6 and 1.2 days, respectively. In the first group (Ampicillin) a 'second wave of fever' occurred in one case (5%) and in the second group (Amoxycillin), in 0% (as compared to 22% after treatment with benzylpenicillin). On the basis of our experiences, Ampicillin and Amoxycillin are strongly recommended for the treatment of human Leptospira infections.
氨苄西林（半合成青霉素）和阿莫西林（羟氨苄青霉素）在体外和体内均有很强的杀钩端螺旋体作用。我们对28例钩端螺旋体感染患者进行了这些药物的试验。患者通常口服，每天服用3克氨苄西林（半合成青霉素）或2克阿莫西林（羟氨苄青霉素），持续6天。在接受氨苄西林和阿莫西林治疗的组中，治疗期间发热的平均持续时间分别为1.6天和1.2天。在第一组（氨苄西林）中，有1例（5%）出现“二次发热波”，而在第二组（阿莫西林）中，出现率为0%（与苄青霉素治疗后22%的出现率相比）。根据我们的经验，强烈推荐使用氨苄西林和阿莫西林治疗人类钩端螺旋体感染。
