Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, P. R. China.
J Mater Chem B. 2019 Dec 11;7(48):7729-7735. doi: 10.1039/c9tb02060h.
Titanium carbides (Ti3C2), a new family of two-dimensional (2D) nanomaterials, have attracted extensive attention due to their unique structure and desirable physiochemical properties. Herein, we developed an effective and selective fluorescent turn-on nanosensor for glucose detection based on Ti3C2 nanosheets combined with red-emitting carbon dots (RCDs). The fluorescence intensity of RCDs could be effectively quenched (>96%) by Ti3C2 nanosheets through the inner-filter effect (IFE). In the presence of H2O2, the quenched fluorescence of the RCDs can remarkably recover due to the Ti3C2 nanosheets which were oxidized into Ti(OH)4 by H2O2. Based on H2O2 generated from oxidation of glucose catalyzed by glucose oxidase, the nanosensor can also be exploited for monitoring glucose. Under optimal conditions, a linear relationship between the increased fluorescence intensity of RCDs and the concentration of glucose was established in the range from 0.1 to 20 mM. The detection limit was 50 μM (S/N = 3). The proposed nanosensor also represented excellent selectivity for glucose analysis in biological fluid samples, providing a valuable platform for glucose sensing in clinical diagnostics.
碳化钛（Ti3C2），一种新型二维（2D）纳米材料，由于其独特的结构和理想的物理化学性质而受到广泛关注。在此，我们开发了一种基于 Ti3C2 纳米片结合红色发光碳点（RCDs）的有效且选择性的荧光开启型纳米传感器，用于葡萄糖检测。RCDs 的荧光强度可以通过内滤效应（IFE）有效地被 Ti3C2 纳米片猝灭（>96%）。在 H2O2 的存在下，由于 H2O2 将 Ti3C2 纳米片氧化成 Ti(OH)4，猝灭的 RCDs 荧光可以显著恢复。基于葡萄糖氧化酶催化氧化产生的 H2O2，该纳米传感器也可用于监测葡萄糖。在最佳条件下，RCDs 的荧光强度与葡萄糖浓度在 0.1 至 20 mM 的范围内呈线性关系。检测限为 50 μM（S/N = 3）。该纳米传感器还在生物流体样品的葡萄糖分析中表现出优异的选择性，为临床诊断中的葡萄糖传感提供了有价值的平台。
