Pharmakologisches Institut, Technische Universität München, Biedersteiner Str. 29, D-80802 München, Germany.
Biol Chem. 2020 Mar 26;401(4):447-469. doi: 10.1515/hsz-2019-0386.
The cyclic guanosine monophosphate (cGMP) signaling system is one of the most prominent regulators of a variety of physiological and pathophysiological processes in many mammalian and non-mammalian tissues. Targeting this pathway by increasing cGMP levels has been a very successful approach in pharmacology as shown for nitrates, phosphodiesterase (PDE) inhibitors and stimulators of nitric oxide-guanylyl cyclase (NO-GC) and particulate GC (pGC). This is an introductory review to the cGMP signaling system intended to introduce those readers to this system, who do not work in this area. This article does not intend an in-depth review of this system. Signal transduction by cGMP is controlled by the generating enzymes GCs, the degrading enzymes PDEs and the cGMP-regulated enzymes cyclic nucleotide-gated ion channels, cGMP-dependent protein kinases and cGMP-regulated PDEs. Part A gives a very concise introduction to the components. Part B gives a very concise introduction to the functions modulated by cGMP. The article cites many recent reviews for those who want a deeper insight.
环鸟苷酸（cGMP）信号系统是许多哺乳动物和非哺乳动物组织中多种生理和病理生理过程的最主要调节因子之一。通过增加 cGMP 水平来靶向该途径，在药理学中已经是一种非常成功的方法，如硝酸盐、磷酸二酯酶（PDE）抑制剂、一氧化氮-鸟苷酸环化酶（NO-GC）和颗粒鸟苷酸环化酶（pGC）的刺激剂所示。本文是对 cGMP 信号系统的介绍性综述，旨在向不从事该领域工作的读者介绍该系统。本文无意对此系统进行深入的综述。cGMP 的信号转导受生成酶 GC、降解酶 PDE 和 cGMP 调节的酶环核苷酸门控离子通道、cGMP 依赖性蛋白激酶和 cGMP 调节的 PDE 控制。A 部分非常简洁地介绍了组成部分。B 部分非常简洁地介绍了 cGMP 调节的功能。对于那些想要更深入了解的人，本文引用了许多最新的评论。
