Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science & Bioengineering, Beijing University of Technology, Beijing 100124, China.
Chem Commun (Camb). 2019 Dec 18;55(97):14685-14688. doi: 10.1039/c9cc07840a. Epub 2019 Nov 21.
Herein the first example of electrochemically enabled, NiCl-catalyzed reductive decarboxylative coupling of N-hydroxyphthalimide (NHP) esters with quinoxalinones is reported. A range of primary, secondary, tertiary aliphatic carboxylic acids and amino acid-derived esters were tolerated well. This decarboxylative coupling allows access to structurally diverse 3-alkylated quinoxalinones in up to 91% yields.
本文首次报道了电化学促进的、NiCl 催化的 N-羟基邻苯二甲酰亚胺（NHP）酯与喹喔啉酮的还原脱羧偶联反应。该反应对一系列伯、仲、叔脂肪族羧酸和氨基酸衍生的酯均具有良好的耐受性。该脱羧偶联反应可以得到结构多样的 3-烷基化喹喔啉酮，产率高达 91%。
