抗氧化活性失调和碳水化合物代谢在乳糜泻中的关键作用。
The critical role of dysregulation of antioxidant activity and carbohydrate metabolism in celiac disease.
作者信息
KhalKhal Ensieh, Rezaei-Tavirani Mostafa, Razzaghi Mohammadreza, Rezaei-Tavirani Sina, Zali Hakimeh, Rostamii-Nejad Mohammad
机构信息
Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Gastroenterol Hepatol Bed Bench. 2019 Fall;12(4):340-347.
AIM
Identification of the important processes and the related genes that are dis-regulated in the celiac disease (CD) was the aim of this study.
BACKGROUND
Celiac disease is an autoimmune disorder which is characterized by immune reaction response mostly to wheat gluten. The gluten-free diet is the best-known treatment of the patients.
METHODS
Significant differentially expressed proteins (DEPs) related to the CD are extracted from a published proteomics study and are included in protein-protein interaction PPI) network analysis by Cytoscape software and its applications. The central proteins and related processes are identified and discussed.
RESULTS
Among 53 queried genes, 51 individuals were recognized by the database, and after network construction, 48 ones included in the network, and three genes remained as isolated nodes. Following 50 neighbors, the network was analyzed, and eight central genes were identified as dis-regulated elements. Related processes and the role of the central genes in celiac are discussed in detail.
CONCLUSION
CAT, ENO1, PCK2, ACO2, ALDOOB, GALM, ADA, and ACTBADA as critical genes and Antioxidant activity, carbohydrate metabolism, inflammation, cell growth processes are highlighted as the dis-regulated individuals in CD.
目的
本研究旨在鉴定乳糜泻（CD）中失调的重要过程及相关基因。
背景
乳糜泻是一种自身免疫性疾病，其特征主要是对小麦麸质产生免疫反应。无麸质饮食是已知的针对患者的最佳治疗方法。
方法
从一项已发表的蛋白质组学研究中提取与乳糜泻相关的显著差异表达蛋白（DEPs），并通过Cytoscape软件及其应用程序纳入蛋白质 - 蛋白质相互作用（PPI）网络分析。鉴定并讨论核心蛋白及相关过程。
结果
在53个查询基因中，数据库识别出51个个体，构建网络后，48个基因包含在网络中，3个基因作为孤立节点保留。分析50个邻居后的网络，鉴定出8个核心基因作为失调元件。详细讨论了相关过程以及核心基因在乳糜泻中的作用。
结论
CAT、ENO1、PCK2、ACO2、ALDOOB、GALM、ADA和ACTBADA作为关键基因，抗氧化活性、碳水化合物代谢、炎症、细胞生长过程被突出显示为乳糜泻中失调的个体。
Zotero 插件