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在老年马来西亚人中,膝关节疼痛和骨关节炎症状的流行率、社会经济和健康相关危险因素存在种族差异。

Ethnic differences in the prevalence, socioeconomic and health related risk factors of knee pain and osteoarthritis symptoms in older Malaysians.

机构信息

Ageing and Age-Associated Disorders Research Group, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Research Management Centre, Perdana University, Serdang, Selangor, Malaysia.

出版信息

PLoS One. 2019 Nov 21;14(11):e0225075. doi: 10.1371/journal.pone.0225075. eCollection 2019.

DOI:10.1371/journal.pone.0225075
PMID:31751378
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6874060/
Abstract

Knee pain is often underreported, underestimated and undertreated. This study was conducted to estimate the prevalence, burden and further identify socioeconomic factors influencing ethnic differences in knee pain and symptoms of OA among older adults aged 55 years and over in Greater Kuala Lumpur (the capital city of Malaysia). The sample for the Malaysian Elders Longitudinal Research (MELoR) was selected using stratified random sampling, by age and ethnicity from the electoral rolls of three parliamentary constituencies. Information on knee pain was available in 1226 participants, mean age (SD) 68.96 (1.57) years (409 Malay, 416 Chinese, 401 Indian). The crude and weighted prevalence of knee pain and self-reported knee OA symptoms were 33.3% and 30.8% respectively. There were significant ethnic differences in knee pain (crude prevalence: Malays 44.6%, Chinese 23.5% and Indians 31.9%, p<0.001). The presence of two or more non-communicable diseases (NCD) attenuated the increased risk of knee pain among the ethnic Indians compared to the ethnic Chinese. The prevalence of knee pain remained significantly higher among the ethnic Malays after adjustment for confounders. While the prevalence of knee pain in our older population appears similar to that reported in other published studies in Asia, the higher prevalence among the ethnic Malays has not previously been reported. Further research to determine potential genetic susceptibility to knee pain among the ethnic Malays is recommended.

摘要

膝关节疼痛常常被低估、忽视和治疗不足。本研究旨在估计 55 岁及以上吉隆坡大都市区(马来西亚首都)老年人膝关节疼痛和骨关节炎症状的患病率、负担,并进一步确定影响其种族差异的社会经济因素。马来西亚老年人纵向研究(MELoR)的样本采用分层随机抽样,根据年龄和种族从三个议会选区的选民名单中抽取。1226 名参与者中有膝关节疼痛信息,平均年龄(SD)为 68.96(1.57)岁(409 名马来人,416 名华人,401 名印度人)。膝关节疼痛的粗患病率和加权患病率分别为 33.3%和 30.8%。膝关节疼痛存在显著的种族差异(粗患病率:马来人 44.6%,华人 23.5%,印度人 31.9%,p<0.001)。与华人相比,存在两种或两种以上非传染性疾病(NCD)会减弱印度人患膝关节疼痛的风险。调整混杂因素后,马来人膝关节疼痛的患病率仍然明显较高。虽然我们老年人群体的膝关节疼痛患病率与亚洲其他已发表研究报告的患病率相似,但马来人患病率较高的情况以前尚未报道过。建议进一步研究以确定马来人膝关节疼痛的潜在遗传易感性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee9f/6874060/8c111c029fa1/pone.0225075.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee9f/6874060/8c35ecce1bf0/pone.0225075.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee9f/6874060/8c111c029fa1/pone.0225075.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee9f/6874060/8c35ecce1bf0/pone.0225075.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee9f/6874060/8c111c029fa1/pone.0225075.g002.jpg

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