Ageing and Age-Associated Disorders Research Group, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Clin Auton Res. 2020 Apr;30(2):121-128. doi: 10.1007/s10286-019-00610-2. Epub 2019 May 11.
To determine the lifetime cumulative incidence of syncope, potential ethnic differences and factors associated with syncope using the Malaysian elders longitudinal research (MELoR) study first wave dataset.
The MELoR study recruited community-dwelling adults aged 55 years and over, selected through stratified random sampling from three parliamentary constituencies. The baseline data collected during the first wave was obtained through face-to-face interviews in participants' homes using computer-assisted questionnaires. During their baseline assessments, participants were asked whether they had ever experienced a blackout in their lifetime and if they had experienced a blackout in the preceding 12 months.
Information on blackouts and ethnicity were available for 1530 participants. The weight-adjusted lifetime cumulative incidence of syncope for the overall population aged 55 years and above was 27.7%. The estimated lifetime cumulative incidence according to ethnic groups was 34.6% for Malays, 27.8% for Indians and 23.7% for Chinese. The estimated 12-month incidence of syncope was 6.1% overall, equating to 11.7% for Malays, 8.7 % for Indians and 2.3% for Chinese. Both Malay [odds ratio (OR) 1.46; 95% confidence interval (CI) 1.10-1.95 and OR 3.62, 95% CI 1.96-6.68] and Indian (OR 1.34; 95% CI 1.01-1.80 and OR 3.31, 1.78-6.15) ethnicities were independently associated with lifetime and 12-month cumulative incidence of syncope, respectively, together with falls, dizziness and myocardial infarction.
Ethnic differences exist for lifetime cumulative incidence of syncope in community-dwelling individuals aged 55 years and over in an urban area in Southeast Asia. Future studies should now seek to determine potential genetic, cultural and lifestyle differences which may predispose to syncope.
利用马来西亚老年人纵向研究（MELoR）研究第一波数据集，确定晕厥的终生累积发生率、潜在的种族差异以及与晕厥相关的因素。
MELoR 研究招募了年龄在 55 岁及以上的社区居民，通过从三个选区进行分层随机抽样选择。第一波收集的基线数据是通过使用计算机辅助问卷在参与者家中进行面对面访谈获得的。在基线评估期间，参与者被问及他们一生中是否经历过晕厥，以及他们在过去 12 个月中是否经历过晕厥。
共有 1530 名参与者提供了晕厥和种族信息。55 岁及以上总人口的加权终生晕厥累积发生率为 27.7%。根据种族群体估计的终生累积晕厥发生率分别为马来人 34.6%、印度人 27.8%和中国人 23.7%。总体 12 个月晕厥发生率为 6.1%，马来人 11.7%、印度人 8.7%和中国人 2.3%。马来人（比值比 [OR] 1.46；95%置信区间 [CI] 1.10-1.95 和 OR 3.62，95% CI 1.96-6.68）和印度人（OR 1.34；95% CI 1.01-1.80 和 OR 3.31，1.78-6.15）的种族均与晕厥的终生和 12 个月累积发生率独立相关，同时还与跌倒、头晕和心肌梗死相关。
在东南亚城市地区，55 岁及以上社区居民的晕厥终生累积发生率存在种族差异。未来的研究现在应该确定可能导致晕厥的潜在遗传、文化和生活方式差异。
