评估一种编码亨德拉病毒可溶性糖蛋白的单剂量核苷修饰信使核糖核酸疫苗对叙利亚仓鼠致死性尼帕病毒攻击的效果。
Evaluation of a Single-Dose Nucleoside-Modified Messenger RNA Vaccine Encoding Hendra Virus-Soluble Glycoprotein Against Lethal Nipah virus Challenge in Syrian Hamsters.
作者信息
Lo Michael K, Spengler Jessica R, Welch Stephen R, Harmon Jessica R, Coleman-McCray JoAnn D, Scholte Florine E M, Shrivastava-Ranjan Punya, Montgomery Joel M, Nichol Stuart T, Weissman Drew, Spiropoulou Christina F
机构信息
Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
出版信息
J Infect Dis. 2020 May 11;221(Suppl 4):S493-S498. doi: 10.1093/infdis/jiz553.
Abstract
In the absence of approved vaccines and therapeutics for use in humans, Nipah virus (NiV) continues to cause fatal outbreaks of encephalitis and respiratory disease in Bangladesh and India on a near-annual basis. We determined that a single dose of a lipid nanoparticle nucleoside-modified messenger RNA vaccine encoding the soluble Hendra virus glycoprotein protected up to 70% of Syrian hamsters from lethal NiV challenge, despite animals having suboptimally primed immune responses before challenge. These data provide a foundation from which to optimize future messenger RNA vaccination studies against NiV and other highly pathogenic viruses.
摘要
在缺乏已批准用于人类的疫苗和治疗方法的情况下，尼帕病毒（NiV）几乎每年都在孟加拉国和印度引发致命的脑炎和呼吸道疾病疫情。我们确定，单剂量编码可溶性亨德拉病毒糖蛋白的脂质纳米颗粒核苷修饰信使核糖核酸疫苗可保护高达70%的叙利亚仓鼠免受致命的尼帕病毒攻击，尽管动物在攻击前的免疫反应启动情况欠佳。这些数据为优化未来针对尼帕病毒和其他高致病性病毒的信使核糖核酸疫苗接种研究奠定了基础。
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Nat Struct Mol Biol. 2019 Oct;26(10):980-987. doi: 10.1038/s41594-019-0308-9. Epub 2019 Sep 30.
2
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J Infect Dis. 2019 May 24;219(12):1855-1857. doi: 10.1093/infdis/jiy611.
3
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J Exp Med. 2018 Jun 4;215(6):1571-1588. doi: 10.1084/jem.20171450. Epub 2018 May 8.
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Nat Rev Drug Discov. 2018 Apr;17(4):261-279. doi: 10.1038/nrd.2017.243. Epub 2018 Jan 12.
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J Infect Dis. 2018 Jan 17;217(3):451-455. doi: 10.1093/infdis/jix592.
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