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2
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3
Current status of imaging in nonalcoholic fatty liver disease.非酒精性脂肪性肝病的影像学现状
World J Hepatol. 2018 Aug 27;10(8):530-542. doi: 10.4254/wjh.v10.i8.530.
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Omega-3 fatty acids and non-alcoholic fatty liver disease: Evidence of efficacy and mechanism of action.ω-3 脂肪酸与非酒精性脂肪性肝病：疗效证据与作用机制。
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Nutr Metab (Lond). 2018 Jan 29;15:10. doi: 10.1186/s12986-018-0241-7. eCollection 2018.
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Annu Rev Pathol. 2018 Jan 24;13:321-350. doi: 10.1146/annurev-pathol-020117-043617.
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Non-alcoholic fatty liver disease (NAFLD) - pathogenesis, classification, and effect on drug metabolizing enzymes and transporters.非酒精性脂肪性肝病（NAFLD）——发病机制、分类以及对药物代谢酶和转运体的影响
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血液中的脂肪酸谱是肝脏变化的良好预测指标吗？脂肪酸谱与肝脏中脂肪酸含量的相关性。

Is the Fatty Acids Profile in Blood a Good Predictor of Liver Changes? Correlation of Fatty Acids Profile with Fatty Acids Content in the Liver.

作者信息

Maciejewska Dominika, Palma Joanna, Dec Karolina, Skonieczna-Żydecka Karolina, Gutowska Izabela, Szczuko Małgorzata, Jakubczyk Karolina, Stachowska Ewa

机构信息

Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.

Department of Medical Chemistry, Pomeranian Medical University in Szczecin, 70-204 Szczecin, Poland.

出版信息

Diagnostics (Basel). 2019 Nov 19;9(4):197. doi: 10.3390/diagnostics9040197.

DOI:10.3390/diagnostics9040197
PMID:31752380
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6963765/
Abstract

BACKGROUND

Existing data show a correlation between the profile of fatty acids, liver, and blood. Therefore, the aim of our study was to investigate the correlation between the fatty acids profile in blood pallets and the liver.

METHODS

The experiment was performed on 60 eight-week-old male Sprague-Dawley rats. The study group ( = 30, 5 groups, 6 rats each) received a cholesterol diet; the control group ( = 30, 5 groups, 6 rats each) received standard food for laboratory rats. The rats from both the study and control groups were sacrificed after 2, 4, 8, 12, and 16 weeks of dietary exposure. The fatty acids profile was measured using gas chromatography (GC).

RESULTS

In both the control and study group, the highest correlations were observed in palmitoleic acid (RHO = 0.68), heptadecanoic acid (RHO = 0.65), vaccenic acid (RHO = 0.72), eicosapentaenoic acid (RHO = 0.68), docosapentaenoic acid (RHO = 0.77), and docosahexaenoic (RHO = 0.77). Among liver indexes, the highest correlations were desaturase-18 (0.61).

CONCLUSIONS

Fatty acids profile is a sensitive marker of the development of potentially pathological changes in the liver. The potential markers of fatty liver are: oleic acid, vaccenic acid, EPA, DHA, docosapentaenoic acid, and desaturase index (SCD-18 index).

摘要

背景

现有数据表明脂肪酸谱、肝脏和血液之间存在相关性。因此，我们研究的目的是调查血样中脂肪酸谱与肝脏之间的相关性。

方法

对60只八周龄雄性斯普拉格-道利大鼠进行实验。研究组（n = 30，分为5组，每组6只大鼠）接受胆固醇饮食；对照组（n = 30，分为5组，每组6只大鼠）接受实验室大鼠的标准食物。在饮食暴露2、4、8、12和16周后，对研究组和对照组的大鼠进行处死。使用气相色谱法（GC）测量脂肪酸谱。

结果

在对照组和研究组中，棕榈油酸（RHO = 0.68）、十七烷酸（RHO = 0.65）、反式vaccenic酸（RHO = 0.72）、二十碳五烯酸（RHO = 0.68）、二十二碳五烯酸（RHO = 0.77）和二十二碳六烯酸（RHO = 0.77）的相关性最高。在肝脏指标中，相关性最高的是去饱和酶-18（0.61）。

结论

脂肪酸谱是肝脏潜在病理变化发展的敏感标志物。脂肪肝的潜在标志物是：油酸、反式vaccenic酸、二十碳五烯酸、二十二碳六烯酸、二十二碳五烯酸和去饱和酶指数（SCD-18指数）。