Kikut Justyna, Drozd Arleta, Mokrzycka Małgorzata, Grzybowska-Chlebowczyk Urszula, Ziętek Maciej, Szczuko Małgorzata
Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland.
Department of Pediatrics, Hemato-Oncology and Pediatric Gastroenterology, Independent Public Clinical Hospital No. 1, Pomeranian Medical University in Szczecin, 71-252 Szczecin, Poland.
J Clin Med. 2022 Apr 23;11(9):2365. doi: 10.3390/jcm11092365.
Crohn's disease (CD) and Ulcerative Colitis (UC) are classified as inflammatory bowel diseases (IBD). Currently, an increasing number of studies indicate that the metabolic consequences of IBD may include abnormalities in the fatty acid profile. The aim of this study was to compare fatty acid concentrations in IBD in order to identify differences between CD and UC and differences between the phases of both diseases.
Sixty-three adolescent patients with CD ( = 33) and UC ( = 30) aged 13.66 ± 2.67 and 14.15 ± 3.31, respectively, were enrolled in the study. Analysis was performed by gas chromatography.
A statistically significant higher concentration of vaccenic acid was observed in the total UC group relative to total CD. In remission CD relative to active CD, a significantly higher concentration of palmitic acid was shown. Whereas in active CD, significantly higher levels of linoleic acid were observed relative to remission. The UC group had significantly higher lauric acid and gamma-linoleic acid levels in active disease relative to remission.
The identified differences between FA levels in UC and CD could potentially be involved in the course of both diseases.
克罗恩病（CD）和溃疡性结肠炎（UC）被归类为炎症性肠病（IBD）。目前，越来越多的研究表明，IBD的代谢后果可能包括脂肪酸谱异常。本研究的目的是比较IBD中的脂肪酸浓度，以确定CD和UC之间的差异以及两种疾病各阶段之间的差异。
本研究纳入了63例青少年患者，其中CD患者33例，年龄为13.66±2.67岁；UC患者30例，年龄为14.15±3.31岁。采用气相色谱法进行分析。
相对于CD患者，UC患者组中反式vaccenic酸的浓度具有统计学意义上的显著升高。缓解期CD患者相对于活动期CD患者，棕榈酸浓度显著更高。而在活动期CD患者中，相对于缓解期，亚油酸水平显著更高。UC患者组在疾病活动期相对于缓解期，月桂酸和γ-亚油酸水平显著更高。
UC和CD患者脂肪酸水平的差异可能与两种疾病的病程有关。
