Department of Agricultural, Food & Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada.
Key Laboratory of Smart Drug Delivery of MOE & PLA, School of Pharmacy, Fudan University, Shanghai 201203, PR China.
Nanomedicine (Lond). 2019 Nov;14(21):2853-2871. doi: 10.2217/nnm-2019-0244. Epub 2019 Nov 22.
Oat protein-shellac nanoparticles (NPs) were developed as a delivery system for resveratrol to improve bioavailability. The NPs were prepared from w/w emulsion followed by cold-gelation. release and cell uptake mechanism of NPs were estimated by HPLC and confocal laser scanning microscopy. bioavailability and hepatoprotective activity of encapsulated resveratrol were studied using rat models. NPs (90-300 nm) protected resveratrol in gastric fluid, while allowing controlled release into small intestine . The optimized NPs showed improvement in resveratrol cell uptake and transport when compared with free resveratrol. NP-100S increased resveratrol bioavailability up to 72.4%, and the absorbed resveratrol effectively prevented CCl-induced hepatotoxicity by attenuating oxidative stress.
燕麦蛋白-紫胶纳米粒（NPs）被开发为白藜芦醇的递送系统，以提高其生物利用度。 NPs 通过 w/w 乳液随后冷凝胶化制备。 通过 HPLC 和共聚焦激光扫描显微镜评估 NPs 的释放和细胞摄取机制。 使用大鼠模型研究了包封白藜芦醇的生物利用度和肝保护活性。 NPs（90-300nm）在胃液中保护白藜芦醇，同时允许其在小肠中控制释放。 与游离白藜芦醇相比，优化后的 NPs 显示出对白藜芦醇摄取和转运的改善。 NP-100S 将白藜芦醇的生物利用度提高了 72.4%，吸收的白藜芦醇通过减轻氧化应激有效预防 CCl 引起的肝毒性。
