School of Pharmaceutical Sciences, Lovely Professional University, Phagwara - 144411, Punjab, India.
Curr Drug Deliv. 2020;17(1):52-73. doi: 10.2174/1567201816666191120120551.
Psoriasis is a genetically predisposed autoimmune disease mediated by cytokines released by the activated immune cells. It manifests inflammatory, scaly red or white silvery flaky skin which may be a fluid-filled lesion with soreness and itchiness. The prevalence rate of psoriasis is increasing day by day. Despite having such a high prevalence rate, the treatment of psoriasis is still limited. Hence, there is a need to rethink the various treatment strategies available in the allopathic as well as in the alternative systems of medicine.
Various bibliographic databases of previously published peer-reviewed research papers were explored and systematic data culminated in terms of various treatment strategies used for the management of psoriasis. The prime focus is given towards modern as well as alternative systems of medicine such as phototherapy, a combination of phototherapy with pharmacotherapy such as Ayurveda, Yoga and naturopathy, Unani, Siddha, and Homeopathy to treat psoriasis.
A comprehensive review of 161 papers, including both research and review articles, was carried out to make the article readily understandable. The pathogenesis including inflammatory mediators and type of psoriasis is discussed before the treatment strategies to understand the pathophysiology of the disease. The uniqueness, procedure, advantages, and limitations of conventional, advanced, and traditional systems of medicine to treat psoriasis are discussed in detail. Emphasis has also been given towards marine sources such as fish oil, marine sponges, and algae.
Although there are many modern and alternative treatment strategies available to treat psoriasis, none of them have been proven to provide complete relief to patients. Moreover, they are associated with certain side effects. In order to overcome them, novel drug delivery systems have been utilized and found effective; however, their stability and safety become the major impediments towards their successful positioning. Traditional and alternative treatment strategies have found to be safe and effective but their use is localized to certain areas. In a nutshell, to achieve successful treatment of psoriasis, there is a need to focus on the development of stable and non-toxic novel drug delivery systems or the promotion of traditional systems to treat psoriasis.
银屑病是一种由激活的免疫细胞释放的细胞因子介导的遗传易感自身免疫性疾病。它表现为炎症、鳞屑、红色或白色的银鳞状皮肤，可能是伴有疼痛和瘙痒的充满液体的损伤。银屑病的患病率日益增高。尽管患病率如此之高，但银屑病的治疗仍然有限。因此，有必要重新思考在对抗疗法和替代医学系统中可用的各种治疗策略。
探索了以前发表的同行评议研究论文的各种文献数据库，并对各种治疗策略进行了系统的数据总结，以用于管理银屑病。重点放在现代和替代医学系统上，如光疗、光疗与药物治疗的结合，如阿育吠陀、瑜伽和顺势疗法、尤纳尼、悉达和顺势疗法治疗银屑病。
对 161 篇论文进行了全面综述，包括研究和综述文章，以使文章易于理解。在讨论治疗策略之前，先讨论发病机制，包括炎症介质和银屑病的类型，以了解疾病的病理生理学。详细讨论了常规、先进和传统医学系统治疗银屑病的独特性、程序、优点和局限性。还强调了鱼油、海洋海绵和藻类等海洋来源。
尽管有许多现代和替代治疗策略可用于治疗银屑病，但没有一种被证明能为患者提供完全缓解。此外，它们还与某些副作用有关。为了克服这些问题，已经利用了新型药物输送系统，并发现它们是有效的；然而，它们的稳定性和安全性成为成功定位的主要障碍。传统和替代治疗策略已被证明是安全有效的，但它们的使用仅限于某些地区。总之，为了成功治疗银屑病，需要专注于开发稳定和无毒的新型药物输送系统，或推广传统系统来治疗银屑病。
