犬腺病毒 1 型引起 5 周龄幼犬出现神经症状。
Canine adenovirus type 1 causing neurological signs in a 5-week-old puppy.
机构信息
Department of Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, S7N 5B4, Canada.
Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, S7N 5B4, Canada.
出版信息
BMC Vet Res. 2019 Nov 21;15(1):418. doi: 10.1186/s12917-019-2173-5.
BACKGROUND
Infectious canine hepatitis is a rarely encountered disease, that is caused by Canine Adenovirus-1. Clinical signs can vary dramatically, and neurological signs are rarely seen. Neurological manifestation of this disease is rarely reported in the veterinary literature.
CASE PRESENTATION
A 5-week-old, male entire Husky cross puppy presented for a one-day history of abnormal neurological behaviour (circling, ataxia, vocalization and obtund mentation). The puppy was euthanized shortly after presentation due to rapid deterioration. Histopathology raised concerns for Canine Adenovirus 1 (CAdV-1) based on vasculitis in the brain and intranuclear inclusion bodies in endothelial cell and hepatocytes; immunohistochemistry on brain tissue confirmed CAdV-1 infection.
CONCLUSIONS
This report discusses possible routes of infection and manifestations of adenovirus infections causing neurologic signs. It also provides a timely reminder that CAdV-1 should be considered a differential in unvaccinated dogs that present with neurological signs. Further studies are required to better understand the neurotrophic tendencies of this virus.
背景
犬传染性肝炎是一种罕见的疾病，由犬腺病毒 1 引起。临床症状差异很大，很少出现神经症状。这种疾病的神经表现在兽医文献中很少报道。
病例介绍
一只 5 周大的雄性哈士奇幼犬出现异常神经行为（转圈、共济失调、发声和意识障碍）的病史为 1 天。由于病情迅速恶化，该犬在就诊后不久被安乐死。组织病理学检查提示脑血管炎和内皮细胞及肝细胞内的核内包涵体提示犬腺病毒 1（CAdV-1）感染；脑组织免疫组化证实了 CAdV-1 感染。
结论
本报告讨论了导致神经症状的腺病毒感染的可能感染途径和表现。它还及时提醒人们，在未接种疫苗的出现神经症状的犬中，应考虑 CAdV-1 作为鉴别诊断。需要进一步的研究来更好地了解这种病毒的神经营养倾向。
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