G 蛋白激活是否条条大路通罗马？
Do All Roads Lead to Rome in G-Protein Activation?
机构信息
Department of Medicine and Cellular and Molecular Medicine, University of California, San Diego, CA 92093, USA.
Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA.
出版信息
Trends Biochem Sci. 2020 Mar;45(3):182-184. doi: 10.1016/j.tibs.2019.10.010. Epub 2019 Nov 18.
Abstract
High-resolution structural studies on G-protein-coupled receptors (GPCRs) have flourished recently, providing long-sought insights into the dynamic process of guanine nucleotide-binding protein (G-protein) activation. In parallel, analogous studies are starting to shed light on how the same G-proteins are activated by non-GPCR proteins. Can we learn about common themes and variations in G-protein activation from them?
摘要
高分辨率结构研究最近在 G 蛋白偶联受体 (GPCR) 领域蓬勃发展，为长期以来人们对鸟苷酸结合蛋白 (G 蛋白) 激活的动态过程的理解提供了深入的见解。与此同时，类似的研究也开始揭示同样的 G 蛋白如何被非 GPCR 蛋白激活。我们能否从这些研究中了解 G 蛋白激活的共同主题和变化？
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