Partnership for Assessment and Accreditation of Scientific Practice, Heidelberg, Germany.
Janssen Research & Development, Beerse, Belgium.
Eur Neuropsychopharmacol. 2019 Dec;29(12):1312-1320. doi: 10.1016/j.euroneuro.2019.10.007. Epub 2019 Nov 18.
Both positive and negative (null or neutral) results are essential for the progress of science and its self-correcting nature. However, there is general reluctance to publish negative results, and this may be due a range of factors (e.g., the widely held perception that negative results are more difficult to publish, the preference to publish positive findings that are more likely to generate citations and funding for additional research). It is particularly challenging to disclose negative results that are not consistent with previously published positive data, especially if the initial publication appeared in a high impact journal. Ideally, there should be both incentives and support to reduce the costs associated with investing efforts into preparing publications with negative results. We describe here a set of criteria that can help scientists, reviewers and editors to publish technically sound, scientifically high-impact negative (or null) results originating from rigorously designed and executed studies. Proposed criteria emphasize the importance of collaborative efforts and communication among scientists (also including the authors of original publications with positive results).
阳性和阴性（零或中性）结果对于科学的发展及其自我修正性质都是必不可少的。然而，人们普遍不愿意发表阴性结果，这可能是由于一系列因素造成的（例如，普遍认为阴性结果更难发表，人们更喜欢发表更有可能产生引文和为进一步研究提供资金的阳性发现）。披露与先前发表的阳性数据不一致的阴性结果尤其具有挑战性，尤其是如果最初的出版物发表在高影响力的期刊上。理想情况下，应该有激励措施和支持来降低与准备发表阴性结果相关的成本。我们在这里描述了一组标准，可以帮助科学家、审稿人和编辑发表技术上合理、具有科学高影响力的阴性（或零）结果，这些结果源自经过严格设计和执行的研究。提出的标准强调了科学家之间（还包括具有阳性结果的原始出版物的作者）协作努力和沟通的重要性。
