Liu C M, Okuda M
Dept. of Otorhinolaryngology, National Taiwan University Hospital, Taipei.
Rhinology. 1988 Jun;26(2):121-32.
Eosinophils are frequently associated with the manifestation of nasal allergy in the nasal mucosa and nasal secretion. The role of eosinophils in hypersensitivity diseases, however, is still obscure, whether it protects or damages tissues and activates mast cells. The effects of two kinds of human eosinophil extract (biological and physical extracts) on human nasal mucosa by applying them in nasal provocation test and cilia beating test, and also in tracheal ring incubation and skin test in the guinea-pig were measured. The results of the study suggest that eosinophil major protein and other protein components may produce damage to the function of human nasal mucosa and tracheal mucosa of the guinea-pig.
嗜酸性粒细胞常与鼻黏膜和鼻分泌物中的鼻过敏表现相关。然而，嗜酸性粒细胞在超敏反应性疾病中的作用仍不明确，其是保护还是损伤组织以及激活肥大细胞尚不清楚。通过在鼻激发试验和纤毛摆动试验中应用两种人嗜酸性粒细胞提取物（生物提取物和物理提取物），并在豚鼠的气管环孵育和皮肤试验中进行检测，来测定其对人鼻黏膜的影响。研究结果表明，嗜酸性粒细胞主要蛋白和其他蛋白质成分可能会对豚鼠的人鼻黏膜和气管黏膜功能产生损伤。
