豚鼠实验性鼻变态反应中嗜酸性粒细胞的跨上皮迁移

Transepithelial migration of eosinophils in experimental nasal allergy in guinea pigs.

作者信息

Samejima Y, Masuyama K, Ishikawa T

机构信息

Department of Otolaryngology, Kumamoto University, School of Medicine, Japan.

出版信息

Auris Nasus Larynx. 1988;15(1):33-42. doi: 10.1016/s0385-8146(88)80007-5.

DOI:10.1016/s0385-8146(88)80007-5

PMID:3421864

Abstract

We examined eosinophil-migration through the nasal epithelium into nasal cavity in a guinea pig model exhibiting 8-day passive cutaneous anaphylaxis antibody-dependent nasal allergy. Transmission electron microscopic observation of this process revealed that eosinophils traversed the epithelium through the intercellular space and split the tight-junctions of epithelial lining cells. Freeze-fracture studies of this process showed that the morphology of tight-junction was not changed after eosinophil-migration. These observations may indicate that tight-junctions close after eosinophil-migration.

摘要

我们在一个表现出8天被动皮肤过敏反应抗体依赖性鼻过敏的豚鼠模型中，研究了嗜酸性粒细胞通过鼻上皮迁移到鼻腔的过程。对这一过程的透射电子显微镜观察显示，嗜酸性粒细胞通过细胞间隙穿过上皮，并分开上皮衬里细胞的紧密连接。对这一过程的冷冻断裂研究表明，嗜酸性粒细胞迁移后紧密连接的形态没有改变。这些观察结果可能表明嗜酸性粒细胞迁移后紧密连接会关闭。