University of Miami Miller School of Medicine, Miami, FL, 33146, USA.
Department of Medicine, Division of Gastroenterology & Hepatology, University of Miami Health Systems, Miller School of Medicine, 1120 NW 14th Street, Miami, FL, 33136, USA.
Curr Diab Rep. 2019 Nov 21;19(12):142. doi: 10.1007/s11892-019-1273-8.
The goal of this review is to discuss the data on natural alternative sweeteners and their effects on glucose homeostasis and other metabolic parameters within the past five years. We sought to answer whether common natural alternative sweeteners have a positive or negative effect on glucose control in both human and animal models, and whether the data supports their widespread use as a tool to help reduce the prevalence of diabetes and associated comorbid conditions.
Recent studies suggest that natural alternative sweeteners may reduce hyperglycemia, improve lipid metabolism, and have antioxidant effects particularly in those that have baseline diabetes. Diabetes and metabolic syndrome have become a global healthcare crisis and the sugar overconsumption plays a major role. The use of artificial sweeteners has become more prevalent to improve insulin resistance in those with diabetes, obesity, and metabolic syndrome, although the evidence does not support this result. There are however some promising data to suggest that natural alternative sweeteners may be a better alternative to sugar and artificial sweeteners.
综述目的: 本次综述旨在讨论过去五年内天然代糖及其对葡萄糖稳态和其他代谢参数影响的相关数据。我们旨在解答以下问题:常见的天然代糖对人类和动物模型的血糖控制是否具有积极或消极影响,以及数据是否支持将其广泛用作降低糖尿病及相关合并症患病率的工具。
最新发现: 最近的研究表明,天然代糖可能具有降低高血糖、改善脂质代谢和抗氧化作用,尤其对那些存在基线糖尿病的患者。糖尿病和代谢综合征已成为全球性的医疗保健危机,而糖的过度摄入是主要原因之一。为改善糖尿病、肥胖症和代谢综合征患者的胰岛素抵抗,人工甜味剂的使用越来越普遍,尽管这方面的证据并不支持这一结果。但是,有一些有前景的数据表明,天然代糖可能是糖和人工甜味剂的更好替代品。