叶片提取物的抗氧化活性对患病实验大鼠具有抑制作用：系统评价和荟萃分析。
Antioxidant Activity of Leaf Extracts from Bertoni Exerts Attenuating Effect on Diseased Experimental Rats: A Systematic Review and Meta-Analysis.
机构信息
Department of Computer Science and Biomedical Informatics, University of Thessaly, 35 131 Lamia, Greece.
Department of Mathematics, University of Thessaly, 35 132 Lamia, Greece.
出版信息
Nutrients. 2023 Jul 26;15(15):3325. doi: 10.3390/nu15153325.
Stevia ( Bertoni) is an aromatic plant known for its high sweetening power ascribed to its glycosides. Stevia also contains several bioactive compounds showing antioxidant, antiproliferative, antimicrobial, and anti-inflammatory activities. Since inflammation and oxidative stress play critical roles in the pathogenesis of many diseases, stevia emerges as a promising natural product that could support human health. In this study we set out to investigate the way stevia affects oxidative stress markers (e.g., SOD, CAT, GPx, GSH, MDA) in diseased rats administered stevia leaf extracts or glycosides. To this end, we performed an inclusive literature search, following PRISMA guidelines, and recruited multivariate meta-analysis and meta-regression to synthesize all available data on experimental animal models encountering (a) healthy, (b) diseased, and (c) stevia-treated diseased rats. From the 184 articles initially retrieved, 24 satisfied the eligibility criteria, containing 104 studies. Our results demonstrate that regardless of the assay employed, stevia leaf extracts restored all oxidative stress markers to a higher extent compared to pure glycosides. Meta-regression analysis revealed that results from SOD, CAT, GSH, and TAC assays are not statistically significantly different ( = 0.184) and can be combined in meta-analysis. Organic extracts from stevia leaves showed more robust antioxidant properties compared to aqueous or hydroalcoholic ones. The restoration of oxidative markers ranged from 65% to 85% and was exhibited in all tested tissues. Rats with diabetes mellitus were found to have the highest restorative response to stevia leaf extract administration. Our results suggest that stevia leaf extract can act protectively against various diseases through its antioxidant properties. However, which of each of the multitude of stevia compounds contribute to this effect, and to what extent, awaits further investigation.
甜菊（Bertoni）是一种具有浓郁香气的植物，以其糖苷的高甜度而闻名。甜菊还含有几种具有生物活性的化合物，具有抗氧化、抗增殖、抗菌和抗炎作用。由于炎症和氧化应激在许多疾病的发病机制中起着关键作用，甜菊作为一种有前途的天然产物，有望支持人类健康。在这项研究中，我们着手研究甜菊叶提取物或糖苷给药后疾病大鼠的氧化应激标志物（如 SOD、CAT、GPx、GSH、MDA）的变化方式。为此，我们按照 PRISMA 指南进行了全面的文献检索，并进行了多变量荟萃分析和荟萃回归，以综合所有关于实验动物模型的现有数据，这些模型遇到了（a）健康、（b）患病和（c）甜菊治疗患病大鼠的情况。从最初检索到的 184 篇文章中，有 24 篇符合入选标准，包含 104 项研究。我们的结果表明，无论使用何种测定方法，甜菊叶提取物都能将所有氧化应激标志物恢复到更高的水平，与纯糖苷相比。荟萃回归分析表明，来自 SOD、CAT、GSH 和 TAC 测定的结果没有统计学上的显著差异（=0.184），可以合并进行荟萃分析。甜菊叶的有机提取物显示出比水或水醇提取物更强的抗氧化特性。氧化标志物的恢复范围为 65%至 85%，并在所有测试的组织中表现出来。患有糖尿病的大鼠对甜菊叶提取物的给药表现出最高的恢复反应。我们的结果表明，甜菊叶提取物可以通过其抗氧化特性对各种疾病起到保护作用。然而，每种甜菊化合物对这种作用的贡献程度，以及到什么程度，还有待进一步研究。
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