新型 TMS-EEG 指标用于研究人类大脑两半球间的动力学。
Novel TMS-EEG indexes to investigate interhemispheric dynamics in humans.
机构信息
Non-Invasive Brain Stimulation Unit/Department of Behavioral and Clinical Neurology, Santa Lucia Foundation, Via Ardeatina 354, 00179 Rome, Italy; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, Queen Square 33, WC1N 3BG London, United Kingdom.
Non-Invasive Brain Stimulation Unit/Department of Behavioral and Clinical Neurology, Santa Lucia Foundation, Via Ardeatina 354, 00179 Rome, Italy; Department of System Medicine, University of Tor Vergata, Via Oxford 81, 00133 Rome, Italy.
出版信息
Clin Neurophysiol. 2020 Jan;131(1):70-77. doi: 10.1016/j.clinph.2019.09.013. Epub 2019 Oct 24.
OBJECTIVE
To validate two indexes of interhemispheric signal propagation (ISP) and balance (IHB) by combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG).
METHODS
We used TMS-EEG to non-invasively stimulate the two hemispheres of 50 healthy volunteers and measured interhemispheric dynamics in terms of ISP and IHB. We repeated our evaluation after three weeks to assess the reliability of our indexes. We also tested whether our TMS-EEG measures were correlated with traditional interhemispheric inhibition (IHI), as measured with motor-evoked potentials (MEPs).
RESULTS
Our main results showed that ISP and IHB (1) have a high reproducibility among all the participants tested; (2) have a high test-retest reliability (3) are linearly correlated with IHI, as measured with MEPs.
CONCLUSIONS
The main contribution of this study lies in the proposal of new TMS-EEG cortical measures of interhemispheric dynamics and in their validation in terms of intra- and inter-subject reliability. We also provide the first demonstration of the correlation between ISP and IHI.
SIGNIFICANCE
Our results are relevant for the investigation of interhemispheric dynamics in clinical populations where MEPs are not reliable.
目的
通过经颅磁刺激（TMS）与脑电图（EEG）相结合，验证两种大脑半球间信号传播（ISP）和平衡（IHB）的指标。
方法
我们使用 TMS-EEG 对 50 名健康志愿者的两个半球进行非侵入性刺激，并根据 ISP 和 IHB 测量半球间动力学。我们在三周后重复评估，以评估我们指标的可靠性。我们还测试了我们的 TMS-EEG 测量是否与使用运动诱发电位（MEPs）测量的传统半球间抑制（IHI）相关。
结果
我们的主要结果表明，ISP 和 IHB（1）在所有测试参与者中具有较高的可重复性；（2）具有较高的测试-重测可靠性；（3）与 MEPs 测量的 IHI 呈线性相关。
结论
本研究的主要贡献在于提出了新的 TMS-EEG 皮质半球间动力学测量方法，并对其进行了个体间和个体内可靠性的验证。我们还首次证明了 ISP 和 IHI 之间的相关性。
意义
我们的结果对于 MEPs 不可靠的临床人群中对半球间动力学的研究具有重要意义。
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